Metabolic Disorders in Patients with HIV

• Main Authors: Radu Florentina, Jipa Raluca Elena, Rusu Emilia, Cursaru Raluca, Drăguţ Ramona, Stegaru Daniela, Gheorghiţă Andra Gabriela, Radulian Gabriela
• Format: Article
• Language: English
• Published: Sciendo 2016-12-01
• Series: Romanian Journal of Diabetes Nutrition and Metabolic Diseases
• Subjects: insulin resistance; metabolic disorders; dyslipidemia; diabetes
• Online Access: http://www.degruyter.com/view/j/rjdnmd.2016.23.issue-4/rjdnmd-2016-0046/rjdnmd-2016-0046.xml?format=INT

Human Immunodeficiency Virus (HIV) infection and subsequent antiretroviral therapy (ART) are known to be related to different metabolic disorders. Although ART decreased HIV-associated mortality and morbidity, mortality rates in patients with HIV and ART are 3 to 15 higher than those in the general population. More than 50% of the mortality is due to diseases like: diabetes mellitus (DM), hypertension, cardiovascular diseases (CVD), chronic renal disease and complications following bone fractures. In patients with HIV the metabolic disorders are mainly caused by mithocondrial toxicity, a side effect of ART, and they are represented by: dyslipidemia, lipoatrophy, insulin resistance and diabetes mellitus.