AURKA Increase the Chemosensitivity of Colon Cancer Cells to Oxaliplatin by Inhibiting the TP53-Mediated DNA Damage Response Genes

AURKA Increase the Chemosensitivity of Colon Cancer Cells to Oxaliplatin by Inhibiting the TP53-Mediated DNA Damage Response Genes

AURKA, a cell cycle-regulated kinase, is associated with malignant transformation and progression in many cancer types. We analyzed the expression change of AURKA in pan-cancer and its effect on the prognosis of cancer patients using the TCGA dataset. We revealed that AURKA was extensively elevated...

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Bibliographic Details
Main Authors: Baocong Shan, Ran Zhao, Jian Zhou, Minghui Zhang, Xiaoyu Qi, Tianzhen Wang, Jinan Gong, Yiqi Wu, Yuanyuan Zhu, Weiwei Yang, Yang Zhang, Guangyou Wang, Xiaobo Li
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2020/8916729

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http://dx.doi.org/10.1155/2020/8916729

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