Mechanically Robust Gastroretentive Drug-Delivery Systems Capable of Controlling Dissolution Behaviors of Coground β-Lapachone

Mechanically Robust Gastroretentive Drug-Delivery Systems Capable of Controlling Dissolution Behaviors of Coground β-Lapachone

In this study, we aimed to design a highly swellable and mechanically robust matrix tablet (SMT) as a gastroretentive drug-delivery system (GRDDS) capable of improving the dissolution behavior of β-lapachone with low aqueous solubility. For the preparation of SMTs, the cogrinding technique...

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Bibliographic Details
Main Authors: Hyeongmin Kim, Chung-Lyol Lee, Seohyun Lee, Tae Jin Lee, Iqra Haleem, Younghong Lee, Na Jung Hwang, Kyusun Shim, Dohyun Kim, Jaehwi Lee
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Pharmaceutics
Subjects:
swelling gastroretentive system
cogrinding technique
freeze–thawing method
β-lapachone
dissolution behavior
mechanical strength
Online Access:https://www.mdpi.com/1999-4923/11/6/271

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https://www.mdpi.com/1999-4923/11/6/271

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