Interleukin-35 mitigates the function of murine transplanted islet cells via regulation of Treg/Th17 ratio.

Interleukin-35 mitigates the function of murine transplanted islet cells via regulation of Treg/Th17 ratio.

Pancreatic islet transplantation is a promising treatment for type 1 diabetes (T1D). Interleukin-35 (IL-35) is a recently discovered cytokine that exhibits potent immunosuppressive functions. However, the role of IL-35 in islet transplant rejection remains to be elucidated. In this study, we isolate...

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Bibliographic Details
Main Authors: Yin Zongyi, Zou Funian, Li Hao, Wang Xin, Cheng Ying, Zhang Jialin, Liu Yongfeng, Li Baifeng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5728515?pdf=render

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