Approaches to the treatment of bacterial infections of the respiratory tract based on current data of the microbiome

• Main Authors: N. G. Kolosova, N. A. Geppe, I. A. Dronov
• Format: Article
• Language: Russian
• Published: Ltd. “The National Academy of Pediatric Science and Innovation” 2019-03-01
• Series: Rossijskij Vestnik Perinatologii i Pediatrii
• Subjects: children; microbiome; viral-bacterial interactions; respiratory tract infections; thiamphenicol glycinate acetylcysteinate (tga)
• Online Access: https://www.ped-perinatology.ru/jour/article/view/832

Respiratory infections are mainly caused by viruses or bacteria that often interact. In the upper respiratory tract there is a wide range of commensals and potential pathogenic bacteria that, together with other bacteria, viruses and fungi, form complex ecological networks known collectively as “the microbiome”. It is assumed that this community is constantly exposed to synergistic and competitive interspecific interactions. The microbiome of the respiratory tract is a factor of respiratory health, which changes (respiratory viral infections, inappropriate use of antibiotics) can lead to bacterial complications and the spread of respiratory tract infections in. In the light of current guidelines for limiting the use of systemic antibiotics in case of uncomplicated acute respiratory tract infections, a real alternative is the use of topical antimicrobial agents, for example, thiamphenicol glycinate acetylcysteinate. The article presents the results of the use of the drug in respiratory infections of the upper and lower respiratory tract.