Novel heterocyclic hybrid of 2-(aryl)-1H-indene-1,3(2H)-dione targeting tyrosinase: design, biological evaluation and in silico studies

Novel heterocyclic hybrid of 2-(aryl)-1H-indene-1,3(2H)-dione targeting tyrosinase: design, biological evaluation and in silico studies

Melanogenesis is a process of melanin synthesize, which is a primary response for the pigmentation of human skin. Tyrosinase is a key enzyme, which catalyzes a rate-limiting step of the melanin formation, natural products have shown potent inhibitors, but some of these possess toxicity. Numerous syn...

Full description

Bibliographic Details
Main Authors: Aida Iraji, Ali Nemati, Hona Hosseinpoor, Najmeh Edraki, mahsima Khoshneviszadeh, Mahshid Attarroshan, Hossein Sadeghpour, Mehdi Khoshneviszadeh
Format: Article
Language:English
Published: Shiraz University of Medical Sciences 2020-12-01
Series:Trends in Pharmaceutical Sciences
Subjects:
1
3-indandione
tyrosinase inhibitor
in silico studies
organic synthesis
Online Access:https://tips.sums.ac.ir/article_47117_413de650c0a9c47dd1647abf45d85727.pdf

Similar Items

Similar Items