Potential Antimetastatic Effect of Timosaponin AIII against Human Osteosarcoma Cells through Regulating the Integrin/FAK/Cofilin Axis

Potential Antimetastatic Effect of Timosaponin AIII against Human Osteosarcoma Cells through Regulating the Integrin/FAK/Cofilin Axis

Timosaponin AIII (TSAIII) is a steroidal saponin which demonstrates anti-tumour activities. However, the effect of TSAIII on human osteosarcoma cells remains largely unknown. In this study, we demonstrated that TSAIII exerted a significant inhibitory effect on the distribution of cytoskeletal F-acti...

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Bibliographic Details
Main Authors: Yi-Hsien Hsieh, Wen-Hung Hsu, Shun-Fa Yang, Chung-Jung Liu, Ko-Hsiu Lu, Pei-Han Wang, Renn-Chia Lin
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Pharmaceuticals
Subjects:
TSAIII
human osteosarcoma cell lines
cofilin
metastasis
F-actin
Online Access:https://www.mdpi.com/1424-8247/14/3/260

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