Pathogenic Role of Epstein–Barr Virus in Lung Cancers

Pathogenic Role of Epstein–Barr Virus in Lung Cancers

Human oncogenic viruses account for at least 12% of total cancer cases worldwide. Epstein–Barr virus (EBV) is the first identified human oncogenic virus and it alone causes ~200,000 cancer cases and ~1.8% of total cancer-related death annually. Over the past 40 years, increasing lines of evidence ha...

Full description

Bibliographic Details
Main Authors: David Becnel, Ramsy Abdelghani, Asuka Nanbo, Janardhan Avilala, Jacob Kahn, Li Li, Zhen Lin
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Viruses
Subjects:
non-small cell lung cancer
NSCLC
small cell lung cancer
SCLC
Epstein–Barr virus
EBV
Online Access:https://www.mdpi.com/1999-4915/13/5/877
id doaj-8384f1a6d05243d9ac9646e4ad3b0550
record_format Article
spelling doaj-8384f1a6d05243d9ac9646e4ad3b05502021-05-31T23:40:28ZengMDPI AGViruses1999-49152021-05-011387787710.3390/v13050877Pathogenic Role of Epstein–Barr Virus in Lung CancersDavid Becnel0Ramsy Abdelghani1Asuka Nanbo2Janardhan Avilala3Jacob Kahn4Li Li5Zhen Lin6Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USADepartment of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USANational Research Center for the Control and Prevention of Infectious Diseases, Nagasaki University, Sakamoto, Nagasaki 852-8523, JapanDepartment of Pathology and Laboratory Medicine, Tulane University Health Sciences Center and Tulane Cancer Center, New Orleans, LA 70112, USADepartment of Pathology and Laboratory Medicine, Tulane University Health Sciences Center and Tulane Cancer Center, New Orleans, LA 70112, USAInstitute of Translational Research, Ochsner Clinic Foundation, New Orleans, LA 70121, USADepartment of Pathology and Laboratory Medicine, Tulane University Health Sciences Center and Tulane Cancer Center, New Orleans, LA 70112, USAHuman oncogenic viruses account for at least 12% of total cancer cases worldwide. Epstein–Barr virus (EBV) is the first identified human oncogenic virus and it alone causes ~200,000 cancer cases and ~1.8% of total cancer-related death annually. Over the past 40 years, increasing lines of evidence have supported a causal link between EBV infection and a subgroup of lung cancers (LCs). In this article, we review the current understanding of the EBV-LC association and the etiological role of EBV in lung carcinogenesis. We also discuss the clinical impact of the knowledge gained from previous research, challenges, and future directions in this field. Given the high clinical relevance of EBV-LC association, there is an urgent need for further investigation on this topic.https://www.mdpi.com/1999-4915/13/5/877non-small cell lung cancerNSCLCsmall cell lung cancerSCLCEpstein–Barr virusEBV
collection DOAJ
language English
format Article
sources DOAJ
author David Becnel
Ramsy Abdelghani
Asuka Nanbo
Janardhan Avilala
Jacob Kahn
Li Li
Zhen Lin
spellingShingle David Becnel
Ramsy Abdelghani
Asuka Nanbo
Janardhan Avilala
Jacob Kahn
Li Li
Zhen Lin
Pathogenic Role of Epstein–Barr Virus in Lung Cancers
Viruses
non-small cell lung cancer
NSCLC
small cell lung cancer
SCLC
Epstein–Barr virus
EBV
author_facet David Becnel
Ramsy Abdelghani
Asuka Nanbo
Janardhan Avilala
Jacob Kahn
Li Li
Zhen Lin
author_sort David Becnel
title Pathogenic Role of Epstein–Barr Virus in Lung Cancers
title_short Pathogenic Role of Epstein–Barr Virus in Lung Cancers
title_full Pathogenic Role of Epstein–Barr Virus in Lung Cancers
title_fullStr Pathogenic Role of Epstein–Barr Virus in Lung Cancers
title_full_unstemmed Pathogenic Role of Epstein–Barr Virus in Lung Cancers
title_sort pathogenic role of epstein–barr virus in lung cancers
publisher MDPI AG
series Viruses
issn 1999-4915
publishDate 2021-05-01
description Human oncogenic viruses account for at least 12% of total cancer cases worldwide. Epstein–Barr virus (EBV) is the first identified human oncogenic virus and it alone causes ~200,000 cancer cases and ~1.8% of total cancer-related death annually. Over the past 40 years, increasing lines of evidence have supported a causal link between EBV infection and a subgroup of lung cancers (LCs). In this article, we review the current understanding of the EBV-LC association and the etiological role of EBV in lung carcinogenesis. We also discuss the clinical impact of the knowledge gained from previous research, challenges, and future directions in this field. Given the high clinical relevance of EBV-LC association, there is an urgent need for further investigation on this topic.
topic non-small cell lung cancer
NSCLC
small cell lung cancer
SCLC
Epstein–Barr virus
EBV
url https://www.mdpi.com/1999-4915/13/5/877
work_keys_str_mv AT davidbecnel pathogenicroleofepsteinbarrvirusinlungcancers
AT ramsyabdelghani pathogenicroleofepsteinbarrvirusinlungcancers
AT asukananbo pathogenicroleofepsteinbarrvirusinlungcancers
AT janardhanavilala pathogenicroleofepsteinbarrvirusinlungcancers
AT jacobkahn pathogenicroleofepsteinbarrvirusinlungcancers
AT lili pathogenicroleofepsteinbarrvirusinlungcancers
AT zhenlin pathogenicroleofepsteinbarrvirusinlungcancers
_version_ 1721416950911860736

Similar Items