Azacytidine prevents experimental xenogeneic graft-versus-host disease without abrogating graft-versus-leukemia effects

Azacytidine prevents experimental xenogeneic graft-versus-host disease without abrogating graft-versus-leukemia effects

The demethylating agent 5-azacytidine (AZA) has proven its efficacy in the treatment of myelodysplastic syndrome and acute myeloid leukemia. In addition, AZA can demethylate FOXP3 intron 1 (FOXP3i1) leading to the generation of regulatory T cells (Treg). Here, we investigated the impact of AZA on xe...

Full description

Bibliographic Details
Main Authors:	Grégory Ehx, Gilles Fransolet, Laurence de Leval, Stéphanie D'Hondt, Sophie Lucas, Muriel Hannon, Loïc Delens, Sophie Dubois, Pierre Drion, Yves Beguin, Stéphanie Humblet-Baron, Frédéric Baron
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2017-05-01
Series:	OncoImmunology
Subjects:	azacytidine graft-vs.-host disease graft-vs.-leukemia effect nod-scid il-2rγnull regulatory t cells
Online Access:	http://dx.doi.org/10.1080/2162402X.2017.1314425

Similar Items

Azacytidine mitigates experimental sclerodermic chronic graft-versus-host disease
by: Gilles Fransolet, et al.
Published: (2016-07-01)

Brazilian workshop model to train investigators in chronic graft-versus-host disease clinical trials according to the 2005-2006 National Institutes of Health recommendations
by: Rita de Cássia Barbosa da Silva Tavares, et al.
Published: (2011-10-01)

Rehabilitation in Children With Sclerodermoid Chronic Graft-Versus-Host Disease: Case Series
by: Minji Jung, et al.
Published: (2019-06-01)

Targeting the Human T-Cell Inducible COStimulator Molecule with a Monoclonal Antibody Prevents Graft-vs-Host Disease and Preserves Graft vs Leukemia in a Xenograft Murine Model
by: Aude Burlion, et al.
Published: (2017-06-01)

Comparison of Mesenchymal Stromal Cells From Different Origins for the Treatment of Graft-vs.-Host-Disease in a Humanized Mouse Model
by: Céline Grégoire, et al.
Published: (2019-04-01)

<b>Treatments and supportive therapies for oral manifestations of chronic graft-versus-host disease
by: Rafaella Gabriel Maiolino, et al.
Published: (2016-06-01)

Comparison of the Efficacy of Topical Triamcinolone in Orabase and Curcumin in Orabase in Oral Graft-versus-Host Disease
by: Arash Mansourian, et al.
Published: (2017-12-01)

Immune reconstitution and graft-versus-host reactions in rat models of allogeneic hematopoietic cell transplantation
by: Severin eZinöcker, et al.
Published: (2012-11-01)

Can Graft vs. Leukemia Effect Be Uncoupled From Graft vs. Host Disease? An Examination of Proportions
by: Elizabeth Krieger, et al.
Published: (2020-04-01)

Positive Effects of Oral Antibiotic Administration in Murine Chronic Graft-versus-Host Disease
by: Shinri Sato, et al.
Published: (2021-04-01)

Experimental Pharmaceuticals for Steroid-Refractory Acute Graft-versus-Host Disease
by: Abedin S, et al.
Published: (2020-11-01)

Bone Marrow Transplantation 1957-2019
by: Elizabeth Simpson, et al.
Published: (2019-06-01)

Xenogeneic Graft-Versus-Host Disease in Humanized NSG and NSG-HLA-A2/HHD Mice
by: Grégory Ehx, et al.
Published: (2018-08-01)

The Role of Co-stimulatory/Co-inhibitory Signals in Graft-vs.-Host Disease
by: Sandeep Kumar, et al.
Published: (2018-12-01)

Association between human leukocyte antigens and graft-versus-host disease occurrence after allogenic hematopoietic stem cell transplantation
by: Daniela Máira Cardozo, et al.

An Intelligent Clinical Decision Support System for Predicting Acute Graft-versus-host Disease (aGvHD) following Allogeneic Hematopoietic Stem Cell Transplantation
by: Cirruse Salehnasab, et al.
Published: (2021-06-01)

MiR-146a and miR-155 Expression Levels in Acute Graft-Versus-Host Disease Incidence
by: Sadaf eAtarod, et al.
Published: (2016-03-01)

Protecting Intestinal Microenvironment Alleviates Acute Graft-Versus-Host Disease
by: Zhengcan Zhou, et al.
Published: (2021-02-01)

The Evolution of T Cell Depleted Haploidentical Transplantation
by: Franco Aversa, et al.
Published: (2019-11-01)

Mesenchymal Stromal Cells: What Is the Mechanism in Acute Graft-Versus-Host Disease?
by: Neil Dunavin, et al.
Published: (2017-07-01)

Dendritic Cell Regulation of Graft-Vs.-Host Disease: Immunostimulation and Tolerance
by: Hongshuang Yu, et al.
Published: (2019-02-01)

CD4+FOXP3+ Regulatory T Cell Therapies in HLA Haploidentical Hematopoietic Transplantation
by: Antonella Mancusi, et al.
Published: (2019-12-01)

Meibomian Gland Dysfunction in Ocular Graft vs. Host Disease: A Need for Pre-Clinal Models and Deeper Insights
by: Eugene Appenteng Osae, et al.
Published: (2021-03-01)

Helper Innate Lymphoid Cells in Allogenic Hematopoietic Stem Cell Transplantation and Graft Versus Host Disease
by: Linda Quatrini, et al.
Published: (2020-09-01)

T Cell Subsets in Graft Versus Host Disease and Graft Versus Tumor
by: Hua Jiang, et al.
Published: (2021-10-01)

Editorial: Cellular Therapies: Past, Present and Future
by: Ralf Dressel, et al.
Published: (2018-08-01)

Role of HRCT Chest in Post Stem Cell Transplant Recipients Suspected of Pulmonary Complications
by: Abhishek Dwivedi, et al.
Published: (2016-11-01)

Doença enxerto versus hospedeiro aguda A- GVHD Acute graft-versus-host disease
by: Wellington Azevedo
Published: (2010-05-01)

Clinical impact of anti-thymocyte globulin on survival and graft-versus-host disease in patients undergoing human leukocyte antigen mismatched allogeneic stem cell transplantation
by: Taeyun Kim, et al.
Published: (2020-03-01)

Intestinal acute graft versus host disease
by: E Danse, et al.
Published: (2010-03-01)

Computational Analysis of HLA-presentation of Non-synonymous Recipient Mismatches Indicates Effect on the Risk of Chronic Graft-vs.-Host Disease After Allogeneic HSCT
by: Jarmo Ritari, et al.
Published: (2019-07-01)

Network Pharmacology-Guided Development of a Novel Integrative Regimen to Prevent Acute Graft-vs.-Host Disease
by: Ming Lyu, et al.
Published: (2018-12-01)

Optimizing Transplant Approaches and Post-Transplant Strategies for Patients With Acute Myeloid Leukemia
by: Justin Loke, et al.
Published: (2021-04-01)

Pityriasis rubra pilaris‐like graft‐vs‐host disease following allogeneic stem cell transplant in two patients
by: Jennifer Y. Wang, et al.
Published: (2019-12-01)

Treating Steroid Refractory Intestinal Acute Graft-vs.-Host Disease With Fecal Microbiota Transplantation: A Pilot Study
by: Xiaofei Qi, et al.
Published: (2018-09-01)

Targeting Histone Deacetylases to Modulate Graft-Versus-Host Disease and Graft-Versus-Leukemia
by: Sena Kim, et al.
Published: (2020-06-01)

Formaldehyde-treated temporofascial graft versus cartilage graft in repairing failed tympanic membrane grafting
by: Mostafa O. Ramadan, et al.
Published: (2017-10-01)

Inflammatory Cytokine Networks in Gastrointestinal Tract Graft vs. Host Disease
by: Clint Piper, et al.
Published: (2019-02-01)

An Essential Role of Innate Lymphoid Cells in the Pathophysiology of Graft-vs.-Host Disease
by: Liang Shao, et al.
Published: (2019-06-01)

Immunoregulatory CD4-CD8- T cells as a potential therapeutic tool for transplantation, autoimmunity and cancer
by: Erin E Hillhouse, et al.
Published: (2013-01-01)