C1222C Deletion in Exon 8 of ABL1 Is Involved in Carcinogenesis and Cell Cycle Control of Colorectal Cancer Through IRS1/PI3K/Akt Pathway

C1222C Deletion in Exon 8 of ABL1 Is Involved in Carcinogenesis and Cell Cycle Control of Colorectal Cancer Through IRS1/PI3K/Akt Pathway

Colorectal cancer (CRC) is one of the most commonly diagnosed cancers worldwide. ABL1 (c-Abl) is a non-receptor tyrosine kinase, whose role, and molecular mechanism in CRC remain largely unclear. The aim of this study was to elucidate the role of ABL1 to obtain information on colon cancer gene mutat...

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Bibliographic Details
Main Authors: Yi Liu, Jian Cao, Ya-Ning Zhu, Yu Ma, Ghulam Murtaza, Yu Li, Jian-Hua Wang, Yan-Song Pu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Oncology
Subjects:
colorectal cancer
ABL1
mutation
TGF-β1
PI3K/Akt
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01385/full

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