Congenital epidermolysis bullosa: modern methods of diagnosis and therapy. Prospects for regenerative medicine

• Main Authors: Alexey A. Kubanov, Arfenya E. Karamova, Ekaterina S. Monchakovskaya
• Format: Article
• Language: Russian
• Published: State Scientific Center of Dermatovenereology and Cosmetology 2020-03-01
• Series: Vestnik Dermatologii i Venerologii
• Subjects: congenital epidermolysis bullosa; cell therapy; gene therapy; genome editing; viral vectors
• Online Access: https://vestnikdv.ru/jour/article/viewFile/551/1036

Congenital epidermolysis bullosa is a clinically and genetically heterogenous group of hereditary skin diseases characterized by the formation of bullae and/or erosions in response to insignificant mechanical effect. The variety and severity of clinical manifestations of the disease determine the early disablement of patients and the decrease in the quality of life, which requires the development of pathogenetic and etiological methods of treatment. Methods of gene therapy are the most promising direction to study, since they can affect the cause of congenital epidermolysis bullosa.