Mean platelet volume as an inflammatory marker in acute exacerbation of chronic obstructive pulmonary disease
Abstract Background Mean platelet volume (MPV) is affected by inflammation in many conditions, such as in inflammatory bowel diseases, rheumatoid arthritis, and ankylosing spondylitis. Conflicting reports exist about its value in stable and exacerbating chronic obstructive pulmonary disease (COPD)....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2016-02-01
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| Series: | The Egyptian Journal of Bronchology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.4103/1687-8426.176772 |
| Summary: | Abstract Background Mean platelet volume (MPV) is affected by inflammation in many conditions, such as in inflammatory bowel diseases, rheumatoid arthritis, and ankylosing spondylitis. Conflicting reports exist about its value in stable and exacerbating chronic obstructive pulmonary disease (COPD). Objective The aim of the present study was to find out whether there was a significant change in the MPV during acute exacerbation of COPD compared with smokers and healthy controls. Patients and methods The study was carried out on 135 adult patients of both sexes (77 men and 58 women), who presented to Alexandria Main University Hospital. Patients were categorized into three groups of 45 patients each; patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) made up group I, healthy smokers without COPD made up group II, and healthy controls made up group III. Results MPV values were 8.34 ± 0.95 and 9.28 ± 0.67 fl in patients with acute exacerbation of COPD and in smokers, respectively. MPV values in the control group were 9.12 ± 0.60 fl. MPV values were significantly lower in patients of acute exacerbation than in smokers and controls (both, P < 0.001). A positive correlation was found between MPV and measured forced expiratory volume at first second (FEV1), C-reactive protein, and total leukocytic count in total sample. Conclusion MPV was found to be decreased in acute exacerbations of COPD compared with smokers and healthy controls. Evaluation of MPV in COPD exacerbation may indicate systemic inflammation. Thus, MPV may be used as a negative acute-phase reactant in COPD exacerbation. |
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| ISSN: | 1687-8426 2314-8551 |