Low-dose statin pretreatment improves function and prognosis of recurrent ischemic stroke patients

• Main Authors: Chaohua Cui, Shuju Dong, Ning Chen, Jiajia Bao, Li He
• Format: Article
• Language: English
• Published: SAGE Publishing 2020-06-01
• Series: Therapeutic Advances in Neurological Disorders
• Online Access: https://doi.org/10.1177/1756286420920078

Background: Statins are effective in improving the prognosis of stroke patients. In clinical practice, low-dose statins are often administered to stroke patients in Asian countries but their effects on the prognosis of recurrent ischemic stroke patients are still unclear. Methods: Data of consecutive recurrent ischemic stroke patients were prospectively collected. The National Institutes of Health Stroke Scale (NIHSS) of admission and discharge and the modified Rankin scale (mRs) of 90 days after stroke onset were adopted to evaluate primary outcomes. Secondary outcomes included the subgroup analysis. Results: Among 219 patients (mean age 65.41 ± 11.58 years), 150 (68.5%) were male. The low-dose statin group had a higher percentage of milder stroke at admission ( p  < 0.001) and discharge ( p  < 0.001), and favorable functional outcome at 90 days ( p  < 0.001). Univariable regression analysis showed that the use of low-dose statins was inversely associated with higher discharge NIHSS [odds ratio (OR) = 0.36, p  = 0.009] and higher mRs at 90 days (OR = 0.230, p  < 0.001). Multivariable logistic regression analysis revealed that low-dose statins also had a significantly inverse association with higher mRs at 90 days (OR = 0.098, p  = 0.049). According to subgroup analysis, a significant effect was found in the good-persistency subgroup (NIHSS score at discharge: OR = 0.051, p  = 0.004; mRs score at 3 months: OR = 0.053, p  = 0.005), but not in the poor-persistency subgroup. Conclusion: Low-dose statin pretreatment alleviated stroke severity and improved functional outcomes of recurrent stroke patients.