Iron Promotes Dihydroartemisinin Cytotoxicity via ROS Production and Blockade of Autophagic Flux via Lysosomal Damage in Osteosarcoma

Iron Promotes Dihydroartemisinin Cytotoxicity via ROS Production and Blockade of Autophagic Flux via Lysosomal Damage in Osteosarcoma

Osteosarcoma cellular iron concentration is higher than that in normal bone cells and other cell types. High levels of cellular iron help catalyze the Fenton reaction to produce reactive oxygen species (ROS), which promotes cancer cell proliferation. Dihydroartemisinin (DHA), a classic anti-malarial...

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Bibliographic Details
Main Authors: Ying Shen, Bin Zhang, Yanwei Su, Shaikh Atik Badshah, Xiaofei Wang, Xin Li, Yanru Xue, Li Xie, Zhe Wang, Zhouqi Yang, Ge Zhang, Peng Shang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
autophagy
reactive oxygen species
iron
cancer
dihydroartemisinin
lysosome
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00444/full

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