Nrf2-inducing anti-oxidation stress response in the rat liver--new beneficial effect of lansoprazole.

Nrf2-inducing anti-oxidation stress response in the rat liver--new beneficial effect of lansoprazole.

Lansoprazole is a potent anti-gastric ulcer drug that inhibits gastric proton pump activity. We identified a novel function for lansoprazole, as an inducer of anti-oxidative stress responses in the liver. Gastric administration of lansoprazole (10-100 mg/kg) to male Wistar rats produced a dose-depen...

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Bibliographic Details
Main Authors: Yasunobu Yamashita, Takashi Ueyama, Toshio Nishi, Yuta Yamamoto, Akatsuki Kawakoshi, Shogo Sunami, Mikitaka Iguchi, Hideyuki Tamai, Kazuki Ueda, Takao Ito, Yoshihiro Tsuruo, Masao Ichinose
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4028208?pdf=render

Internet

http://europepmc.org/articles/PMC4028208?pdf=render

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