A Novel Mechanism of the c-Myc/NEAT1 Axis Mediating Colorectal Cancer Cell Response to Photodynamic Therapy Treatment

A Novel Mechanism of the c-Myc/NEAT1 Axis Mediating Colorectal Cancer Cell Response to Photodynamic Therapy Treatment

Photodynamic therapy (PDT) is considered a potential treatment regimen for colorectal cancer cases (CRC). p53 signaling and the miR-124/iASPP axis play an essential role in the PDT resistance of CRC cells. PDT treatment downregulated NEAT1 expression in p53wt HCT116 and RKO cells. In these two cell...

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Bibliographic Details
Main Authors: Kuijie Liu, Sanlin Lei, Yong Kuang, Qianqian Jin, Dongju Long, Chao Liu, Yuhong Jiang, Hua Zhao, Hongliang Yao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Oncology
Subjects:
colorectal cancer
photodynamic therapy (PDT)
NEAT1
c-Myc
the miR-124/iASPP/p53 feedback loop
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.652831/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.652831/full

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