Nano-basic silica as an efficient catalyst for the multi-component preparation of pyrano[2,3-d]pyrimidine derivatives

A high-yield protocol is explored for the synthesis of pyrano[2,3-d]pyrimidines through the multi-component reaction of aromatic aldehydes, 1,3-Dimethylbarbituric acid, and malononitrile using nano-basic silica as an efficient catalyst. The method tolerates various electron-donating and electron-wit...

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Main Authors:	Sheikhan-Shamsabadi Nafisehsadat, Ghashang Majid
Format:	Article
Language:	English
Published:	De Gruyter 2017-04-01
Series:	Main Group Metal Chemistry
Subjects:	1,3-dimethylbarbituric acid multi-component reaction nano-basic silica pyrano[2,3-d]pyrimidines
Online Access:	https://doi.org/10.1515/mgmc-2016-0034

id	doaj-833ac38004f94b2da138e6e6282a0eff
record_format	Article
spelling	doaj-833ac38004f94b2da138e6e6282a0eff2021-10-02T19:12:37ZengDe GruyterMain Group Metal Chemistry0792-12412191-02192017-04-01401-2192510.1515/mgmc-2016-0034Nano-basic silica as an efficient catalyst for the multi-component preparation of pyrano[2,3-d]pyrimidine derivativesSheikhan-Shamsabadi Nafisehsadat0Ghashang Majid1Department of Chemistry, Faculty of Sciences, Najafabad Branch, Islamic Azad University, P.O. Box 517, Najafabad, Esfahan, IranDepartment of Chemistry, Faculty of Sciences, Najafabad Branch, Islamic Azad University, P.O. Box 517, Najafabad, Esfahan, IranA high-yield protocol is explored for the synthesis of pyrano[2,3-d]pyrimidines through the multi-component reaction of aromatic aldehydes, 1,3-Dimethylbarbituric acid, and malononitrile using nano-basic silica as an efficient catalyst. The method tolerates various electron-donating and electron-withdrawing groups on the aromatic ring. Nano-basic silica was characterized by field emission scanning electron microscope (FE-SEM) N2 adsorption-desorption isotherm, dynamic light scattering (DLS), and X-ray powder diffraction (XRD) techniques. The particles of nano-basic silica have uniform spheres with sizes that are <100 nm. XRD pattern shows that nano-basic silica is amorphous. The specific surface area and pore volume distribution of nano-basic silica are 663 m2g−1 and 0.634 cm3g−1, respectively.https://doi.org/10.1515/mgmc-2016-00341,3-dimethylbarbituric acidmulti-component reactionnano-basic silicapyrano[2,3-d]pyrimidines
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sheikhan-Shamsabadi Nafisehsadat Ghashang Majid
spellingShingle	Sheikhan-Shamsabadi Nafisehsadat Ghashang Majid Nano-basic silica as an efficient catalyst for the multi-component preparation of pyrano[2,3-d]pyrimidine derivatives Main Group Metal Chemistry 1,3-dimethylbarbituric acid multi-component reaction nano-basic silica pyrano[2,3-d]pyrimidines
author_facet	Sheikhan-Shamsabadi Nafisehsadat Ghashang Majid
author_sort	Sheikhan-Shamsabadi Nafisehsadat
title	Nano-basic silica as an efficient catalyst for the multi-component preparation of pyrano[2,3-d]pyrimidine derivatives
title_short	Nano-basic silica as an efficient catalyst for the multi-component preparation of pyrano[2,3-d]pyrimidine derivatives
title_full	Nano-basic silica as an efficient catalyst for the multi-component preparation of pyrano[2,3-d]pyrimidine derivatives
title_fullStr	Nano-basic silica as an efficient catalyst for the multi-component preparation of pyrano[2,3-d]pyrimidine derivatives
title_full_unstemmed	Nano-basic silica as an efficient catalyst for the multi-component preparation of pyrano[2,3-d]pyrimidine derivatives
title_sort	nano-basic silica as an efficient catalyst for the multi-component preparation of pyrano[2,3-d]pyrimidine derivatives
publisher	De Gruyter
series	Main Group Metal Chemistry
issn	0792-1241 2191-0219
publishDate	2017-04-01
description	A high-yield protocol is explored for the synthesis of pyrano[2,3-d]pyrimidines through the multi-component reaction of aromatic aldehydes, 1,3-Dimethylbarbituric acid, and malononitrile using nano-basic silica as an efficient catalyst. The method tolerates various electron-donating and electron-withdrawing groups on the aromatic ring. Nano-basic silica was characterized by field emission scanning electron microscope (FE-SEM) N2 adsorption-desorption isotherm, dynamic light scattering (DLS), and X-ray powder diffraction (XRD) techniques. The particles of nano-basic silica have uniform spheres with sizes that are <100 nm. XRD pattern shows that nano-basic silica is amorphous. The specific surface area and pore volume distribution of nano-basic silica are 663 m2g−1 and 0.634 cm3g−1, respectively.
topic	1,3-dimethylbarbituric acid multi-component reaction nano-basic silica pyrano[2,3-d]pyrimidines
url	https://doi.org/10.1515/mgmc-2016-0034
work_keys_str_mv	AT sheikhanshamsabadinafisehsadat nanobasicsilicaasanefficientcatalystforthemulticomponentpreparationofpyrano23dpyrimidinederivatives AT ghashangmajid nanobasicsilicaasanefficientcatalystforthemulticomponentpreparationofpyrano23dpyrimidinederivatives
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Nano-basic silica as an efficient catalyst for the multi-component preparation of pyrano[2,3-d]pyrimidine derivatives

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