HGF/c-Met Inhibition as Adjuvant Therapy Improves Outcomes in an Orthotopic Mouse Model of Pancreatic Cancer

HGF/c-Met Inhibition as Adjuvant Therapy Improves Outcomes in an Orthotopic Mouse Model of Pancreatic Cancer

Background: Inhibition of hepatocyte growth factor (HGF)/c-MET pathway, a major mediator of pancreatic stellate cell (PSC)−PC cell interactions, retards local and distant cancer progression. This study examines the use of this treatment in preventing PC progression after resection. We further invest...

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Bibliographic Details
Main Authors: Tony C. Y. Pang, Zhihong Xu, Alpha Raj Mekapogu, Srinivasa Pothula, Therese Becker, Susan Corley, Marc R. Wilkins, David Goldstein, Romano Pirola, Jeremy Wilson, Minoti Apte
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
pancreatic cancer
metastasis
circulating rare cells
circulating pancreatic stellate cells
circulating tumour cells
circulating stromal cells
Online Access:https://www.mdpi.com/2072-6694/13/11/2763

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