Modulation of Circulating MicroRNAs Levels during the Switch from Clopidogrel to Ticagrelor

Background. Circulating microRNAs are appealing biomarkers to monitor several processes underlying cardiovascular diseases. Platelets are a major source for circulating microRNAs. Interestingly, the levels of specific microRNAs were reported to correlate with the level of platelet activation. The ai...

Full description

Bibliographic Details
Main Authors: Annarita Carino, Salvatore De Rosa, Sabato Sorrentino, Alberto Polimeni, Jolanda Sabatino, Gianluca Caiazzo, Daniele Torella, Carmen Spaccarotella, Annalisa Mongiardo, Antonio Strangio, Carol Filippis, Ciro Indolfi
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2016/3968206
id doaj-83210620bdc74e81aed39de974cf26ed
record_format Article
spelling doaj-83210620bdc74e81aed39de974cf26ed2020-11-24T20:57:01ZengHindawi LimitedBioMed Research International2314-61332314-61412016-01-01201610.1155/2016/39682063968206Modulation of Circulating MicroRNAs Levels during the Switch from Clopidogrel to TicagrelorAnnarita Carino0Salvatore De Rosa1Sabato Sorrentino2Alberto Polimeni3Jolanda Sabatino4Gianluca Caiazzo5Daniele Torella6Carmen Spaccarotella7Annalisa Mongiardo8Antonio Strangio9Carol Filippis10Ciro Indolfi11Division of Cardiology, Department of Medical and Surgical Sciences, Magna Græcia University, 88100 Catanzaro, ItalyDivision of Cardiology, Department of Medical and Surgical Sciences, Magna Græcia University, 88100 Catanzaro, ItalyDivision of Cardiology, Department of Medical and Surgical Sciences, Magna Græcia University, 88100 Catanzaro, ItalyDivision of Cardiology, Department of Medical and Surgical Sciences, Magna Græcia University, 88100 Catanzaro, ItalyDivision of Cardiology, Department of Medical and Surgical Sciences, Magna Græcia University, 88100 Catanzaro, ItalyDivision of Cardiology, Department of Medical and Surgical Sciences, Magna Græcia University, 88100 Catanzaro, ItalyDivision of Cardiology, Department of Medical and Surgical Sciences, Magna Græcia University, 88100 Catanzaro, ItalyDivision of Cardiology, Department of Medical and Surgical Sciences, Magna Græcia University, 88100 Catanzaro, ItalyDivision of Cardiology, Department of Medical and Surgical Sciences, Magna Græcia University, 88100 Catanzaro, ItalyDivision of Cardiology, Department of Medical and Surgical Sciences, Magna Græcia University, 88100 Catanzaro, ItalyDivision of Cardiology, Department of Medical and Surgical Sciences, Magna Græcia University, 88100 Catanzaro, ItalyDivision of Cardiology, Department of Medical and Surgical Sciences, Magna Græcia University, 88100 Catanzaro, ItalyBackground. Circulating microRNAs are appealing biomarkers to monitor several processes underlying cardiovascular diseases. Platelets are a major source for circulating microRNAs. Interestingly, the levels of specific microRNAs were reported to correlate with the level of platelet activation. The aim of the present study was to test whether the treatment with the novel antiplatelet agent, ticagrelor, is associated with modulation in the levels of key platelet-derived microRNAs. Methods and Results. Patients were randomly selected from those participating in the SHIFT-OVER study, in which we had previously evaluated the effect of the therapeutic switch from clopidogrel to ticagrelor on platelet aggregation. Circulating levels of selected microRNAs were measured before and after the therapeutic switch from a dual antiplatelet therapy including acetylsalicylic acid (ASA) and clopidogrel to the more potent ticagrelor. Interestingly, the circulating levels of miR-126 (p=0.030), miR-223 (p=0.044), and miR-150 (p=0.048) were significantly reduced, while the levels of miR-96 were increased (p=0.038). No substantial differences were observed for the remaining microRNAs. Conclusions. Switching from a dual antiplatelet treatment with clopidogrel to ticagrelor is associated with significant modulation in the circulating levels of specific microRNAs. If confirmed in larger, independent cohorts, our results pave the way for the use of circulating microRNAs as biomarkers of platelets activity in response to specific pharmacological treatments.http://dx.doi.org/10.1155/2016/3968206
collection DOAJ
language English
format Article
sources DOAJ
author Annarita Carino
Salvatore De Rosa
Sabato Sorrentino
Alberto Polimeni
Jolanda Sabatino
Gianluca Caiazzo
Daniele Torella
Carmen Spaccarotella
Annalisa Mongiardo
Antonio Strangio
Carol Filippis
Ciro Indolfi
spellingShingle Annarita Carino
Salvatore De Rosa
Sabato Sorrentino
Alberto Polimeni
Jolanda Sabatino
Gianluca Caiazzo
Daniele Torella
Carmen Spaccarotella
Annalisa Mongiardo
Antonio Strangio
Carol Filippis
Ciro Indolfi
Modulation of Circulating MicroRNAs Levels during the Switch from Clopidogrel to Ticagrelor
BioMed Research International
author_facet Annarita Carino
Salvatore De Rosa
Sabato Sorrentino
Alberto Polimeni
Jolanda Sabatino
Gianluca Caiazzo
Daniele Torella
Carmen Spaccarotella
Annalisa Mongiardo
Antonio Strangio
Carol Filippis
Ciro Indolfi
author_sort Annarita Carino
title Modulation of Circulating MicroRNAs Levels during the Switch from Clopidogrel to Ticagrelor
title_short Modulation of Circulating MicroRNAs Levels during the Switch from Clopidogrel to Ticagrelor
title_full Modulation of Circulating MicroRNAs Levels during the Switch from Clopidogrel to Ticagrelor
title_fullStr Modulation of Circulating MicroRNAs Levels during the Switch from Clopidogrel to Ticagrelor
title_full_unstemmed Modulation of Circulating MicroRNAs Levels during the Switch from Clopidogrel to Ticagrelor
title_sort modulation of circulating micrornas levels during the switch from clopidogrel to ticagrelor
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2016-01-01
description Background. Circulating microRNAs are appealing biomarkers to monitor several processes underlying cardiovascular diseases. Platelets are a major source for circulating microRNAs. Interestingly, the levels of specific microRNAs were reported to correlate with the level of platelet activation. The aim of the present study was to test whether the treatment with the novel antiplatelet agent, ticagrelor, is associated with modulation in the levels of key platelet-derived microRNAs. Methods and Results. Patients were randomly selected from those participating in the SHIFT-OVER study, in which we had previously evaluated the effect of the therapeutic switch from clopidogrel to ticagrelor on platelet aggregation. Circulating levels of selected microRNAs were measured before and after the therapeutic switch from a dual antiplatelet therapy including acetylsalicylic acid (ASA) and clopidogrel to the more potent ticagrelor. Interestingly, the circulating levels of miR-126 (p=0.030), miR-223 (p=0.044), and miR-150 (p=0.048) were significantly reduced, while the levels of miR-96 were increased (p=0.038). No substantial differences were observed for the remaining microRNAs. Conclusions. Switching from a dual antiplatelet treatment with clopidogrel to ticagrelor is associated with significant modulation in the circulating levels of specific microRNAs. If confirmed in larger, independent cohorts, our results pave the way for the use of circulating microRNAs as biomarkers of platelets activity in response to specific pharmacological treatments.
url http://dx.doi.org/10.1155/2016/3968206
work_keys_str_mv AT annaritacarino modulationofcirculatingmicrornaslevelsduringtheswitchfromclopidogreltoticagrelor
AT salvatorederosa modulationofcirculatingmicrornaslevelsduringtheswitchfromclopidogreltoticagrelor
AT sabatosorrentino modulationofcirculatingmicrornaslevelsduringtheswitchfromclopidogreltoticagrelor
AT albertopolimeni modulationofcirculatingmicrornaslevelsduringtheswitchfromclopidogreltoticagrelor
AT jolandasabatino modulationofcirculatingmicrornaslevelsduringtheswitchfromclopidogreltoticagrelor
AT gianlucacaiazzo modulationofcirculatingmicrornaslevelsduringtheswitchfromclopidogreltoticagrelor
AT danieletorella modulationofcirculatingmicrornaslevelsduringtheswitchfromclopidogreltoticagrelor
AT carmenspaccarotella modulationofcirculatingmicrornaslevelsduringtheswitchfromclopidogreltoticagrelor
AT annalisamongiardo modulationofcirculatingmicrornaslevelsduringtheswitchfromclopidogreltoticagrelor
AT antoniostrangio modulationofcirculatingmicrornaslevelsduringtheswitchfromclopidogreltoticagrelor
AT carolfilippis modulationofcirculatingmicrornaslevelsduringtheswitchfromclopidogreltoticagrelor
AT ciroindolfi modulationofcirculatingmicrornaslevelsduringtheswitchfromclopidogreltoticagrelor
_version_ 1716789017732710400