Effect of tracers molecular weight on the release process from alginate microbeads

• Main Authors: Ilić Jovana M., Grujić Aleksandar S., Stijepović Mirko Z., Stajić-Trošić Jasna T., Bugarski Branko M.
• Format: Article
• Language: English
• Published: Savez inženjera i tehničara Srbije 2015-01-01
• Series: Tehnika
• Subjects: Alginate; tracer; microbeads; diffusion
• Online Access: http://scindeks-clanci.ceon.rs/data/pdf/0040-2176/2015/0040-21761503401I.pdf
• ISSN: 0040-2176; 2560-3086

The aim of this paper is to obtain microbeads of natural polymers such as alginate and chitosan. These microbeads were used as potential carriers for the active ingredients so that in this study the diffusion of various substances from them is analyzed. Alginate microbeads were obtained by electrostatic droplet method. In the resulting microbeads was performed absorption of three tracer indicators with different molecular weight (acridine orange, blue dextran, methylene blue). The goal of the experiment is to monitor indicators release kinetics from microbeads. Based on these measurements the layoffs curve should give an answer on the impact of the molecular size of the three indicators on the diffusion rate of microbeads. In order to achieve the slow release of indicators alginate microbeads were coated with chitosan. Chitosan has an impact on reducing the porosity of gel, which further led to lower release tracer indicators of microbeads. Comparative analysis of the obtained layoffs curves answers about the impact on the process of obtaining micro diffusion rate indicator.