Convenient iron-catalyzed reductive aminations without hydrogen for selective synthesis of N-methylamines

Convenient iron-catalyzed reductive aminations without hydrogen for selective synthesis of N-methylamines

N-methylated amines display high biological activity in living organisms. Here, the authors show the convenient synthesis of a wide range of biologically relevant N-methylamines via reduction of nitrobenzenes using a recyclable iron catalyst and paraformaldehyde without additional hydrogen pressure.

Bibliographic Details
Main Authors: Kishore Natte, Helfried Neumann, Rajenahally V. Jagadeesh, Matthias Beller
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01428-0
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spelling doaj-8318295162d94955a313259e9914ae682021-05-11T07:02:34ZengNature Publishing GroupNature Communications2041-17232017-11-01811910.1038/s41467-017-01428-0Convenient iron-catalyzed reductive aminations without hydrogen for selective synthesis of N-methylaminesKishore Natte0Helfried Neumann1Rajenahally V. Jagadeesh2Matthias Beller3Leibniz-Institute for Catalysis at the University of RostockLeibniz-Institute for Catalysis at the University of RostockLeibniz-Institute for Catalysis at the University of RostockLeibniz-Institute for Catalysis at the University of RostockN-methylated amines display high biological activity in living organisms. Here, the authors show the convenient synthesis of a wide range of biologically relevant N-methylamines via reduction of nitrobenzenes using a recyclable iron catalyst and paraformaldehyde without additional hydrogen pressure.https://doi.org/10.1038/s41467-017-01428-0
collection DOAJ
language English
format Article
sources DOAJ
author Kishore Natte
Helfried Neumann
Rajenahally V. Jagadeesh
Matthias Beller
spellingShingle Kishore Natte
Helfried Neumann
Rajenahally V. Jagadeesh
Matthias Beller
Convenient iron-catalyzed reductive aminations without hydrogen for selective synthesis of N-methylamines
Nature Communications
author_facet Kishore Natte
Helfried Neumann
Rajenahally V. Jagadeesh
Matthias Beller
author_sort Kishore Natte
title Convenient iron-catalyzed reductive aminations without hydrogen for selective synthesis of N-methylamines
title_short Convenient iron-catalyzed reductive aminations without hydrogen for selective synthesis of N-methylamines
title_full Convenient iron-catalyzed reductive aminations without hydrogen for selective synthesis of N-methylamines
title_fullStr Convenient iron-catalyzed reductive aminations without hydrogen for selective synthesis of N-methylamines
title_full_unstemmed Convenient iron-catalyzed reductive aminations without hydrogen for selective synthesis of N-methylamines
title_sort convenient iron-catalyzed reductive aminations without hydrogen for selective synthesis of n-methylamines
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-11-01
description N-methylated amines display high biological activity in living organisms. Here, the authors show the convenient synthesis of a wide range of biologically relevant N-methylamines via reduction of nitrobenzenes using a recyclable iron catalyst and paraformaldehyde without additional hydrogen pressure.
url https://doi.org/10.1038/s41467-017-01428-0
work_keys_str_mv AT kishorenatte convenientironcatalyzedreductiveaminationswithouthydrogenforselectivesynthesisofnmethylamines
AT helfriedneumann convenientironcatalyzedreductiveaminationswithouthydrogenforselectivesynthesisofnmethylamines
AT rajenahallyvjagadeesh convenientironcatalyzedreductiveaminationswithouthydrogenforselectivesynthesisofnmethylamines
AT matthiasbeller convenientironcatalyzedreductiveaminationswithouthydrogenforselectivesynthesisofnmethylamines
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