Sphingosine kinase 1 serves as a pro-viral factor by regulating viral RNA synthesis and nuclear export of viral ribonucleoprotein complex upon influenza virus infection.

Sphingosine kinase 1 serves as a pro-viral factor by regulating viral RNA synthesis and nuclear export of viral ribonucleoprotein complex upon influenza virus infection.

Influenza continues to pose a threat to humans by causing significant morbidity and mortality. Thus, it is imperative to investigate mechanisms by which influenza virus manipulates the function of host factors and cellular signal pathways. In this study, we demonstrate that influenza virus increases...

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Bibliographic Details
Main Authors: Young-Jin Seo, Curtis J Pritzl, Madhuvanthi Vijayan, Kavita Bomb, Mariah E McClain, Stephen Alexander, Bumsuk Hahm
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3796690?pdf=render

Internet

http://europepmc.org/articles/PMC3796690?pdf=render

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