Mathematical analysis of the functional properties of the murine bone marrow in the process of long external gamma-irradiation and after its termination

• Main Authors: R. V. Boiko, D. I. Bіlko, I. Z. Russu, N. M. Bіlko
• Format: Article
• Language: English
• Published: Institute for Nuclear Research, National Academy of Sciences of Ukraine 2016-08-01
• Series: Âderna Fìzika ta Energetika
• Subjects: ionizing radiation; bone marrow; functional properties; mathematical modeling
• Online Access: http://jnpae.kinr.kiev.ua/17.2/html/17.2.0176.html

Mathematical model was applied using the experimental results of prolonged round-the-clock γ-irradiation action with the dose rate of 0.25 and 0.5 Gy/day on the alterations in colony-forming units (CFU) number in murine bone marrow, as well as experimental data, concerning the process of CFU recovery after the termination of 30- and 100-day irradiation. Mathematical parameters were determined which characterize the hematopoiesis reaction to the CFU loss as a result of prolonged ionizing radiation action with different dose rates, as well as the process of CFU number recovery after irradiation termination.