Novel roles of formin mDia2 in lamellipodia and filopodia formation in motile cells.

Novel roles of formin mDia2 in lamellipodia and filopodia formation in motile cells.

Actin polymerization-driven protrusion of the leading edge is a key element of cell motility. The important actin nucleators formins and the Arp2/3 complex are believed to have nonoverlapping functions in inducing actin filament bundles in filopodia and dendritic networks in lamellipodia, respective...

Full description

Bibliographic Details
Main Authors:	Changsong Yang, Lubov Czech, Silke Gerboth, Shin-ichiro Kojima, Giorgio Scita, Tatyana Svitkina
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2007-11-01
Series:	PLoS Biology
Online Access:	http://europepmc.org/articles/PMC2229861?pdf=render

Similar Items

Crystal structure of the Formin mDia1 in autoinhibited conformation.
by: Takanori Otomo, et al.
Published: (2010-09-01)

Coordination of membrane and actin cytoskeleton dynamics during filopodia protrusion.
by: Changsong Yang, et al.
Published: (2009-05-01)

Differential Toxicity of mDia Formin-Directed Functional Agonists and Antagonists in Developing Zebrafish
by: Hunter LeCorgne, et al.
Published: (2018-04-01)

Carcinoma associated fibroblasts (CAFs) promote breast cancer motility by suppressing mammalian Diaphanous-related formin-2 (mDia2).
by: Kaitlyn M Dvorak, et al.
Published: (2018-01-01)

The Formin mDia1 Regulates Acute Lymphoblastic Leukemia Engraftment, Migration, and Progression in vivo
by: Scott B. Thompson, et al.
Published: (2018-09-01)

Properties of the force exerted by filopodia and lamellipodia and the involvement of cytoskeletal components.
by: Dan Cojoc, et al.
Published: (2007-01-01)

The formin protein mDia2 serves as a marker of spindle pole dynamics in vitrified-warmed mouse oocytes.
by: Hyejin Shin, et al.
Published: (2013-01-01)

Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion
by: N. O. Alieva, et al.
Published: (2019-08-01)

Maturation of filopodia shaft adhesions is upregulated by local cycles of lamellipodia advancements and retractions.
by: Wei Hu, et al.
Published: (2014-01-01)

Novel localization of formin mDia2: importin β-mediated delivery to and retention at the cytoplasmic side of the nuclear envelope
by: Xiaowei Shao, et al.
Published: (2015-11-01)

Loss of RhoB expression enhances the myelodysplastic phenotype of mammalian diaphanous-related Formin mDia1 knockout mice.
by: Aaron D DeWard, et al.
Published: (2009-09-01)

Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in platelets
by: Higashi, Tomohito
Published: (2011)

Diaphanous-related formin mDia2 regulates beta2 integrins to control hematopoietic stem and progenitor cell engraftment
by: Yang Mei, et al.
Published: (2020-06-01)

Targeting the mDia Formin-Assembled Cytoskeleton Is an Effective Anti-Invasion Strategy in Adult High-Grade Glioma Patient-Derived Neurospheres
by: Krista M. Pettee, et al.
Published: (2019-03-01)

Crystal structure of a complex between amino and carboxy terminal fragments of mDia1: insights into autoinhibition of diaphanous-related formins.
by: Azin Nezami, et al.
Published: (2010-09-01)

Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia
by: Xuchen Hu, et al.
Published: (2019-09-01)

Overexpression of Fyn induces formation of filopodia and lamellipodia in CHO cells via rearrangement of F-actin
by: Lei An, Yingxue Huang, Lingzhen Song, Wei Zhang, Yamei Zhang, Shulin Chen and Shanting Zhao
Published: (2014-04-01)

Establishment of cell array system and investigation of the downstream signaling of Syndecan-2 in filopodia and lamellipodia formation
by: Ya-Ting Lei, et al.
Published: (2005)

Enteropathogenic E. coli relies on collaboration between the formin mDia1 and the Arp2/3 complex for actin pedestal biogenesis and maintenance.
by: Katrina B Velle, et al.
Published: (2018-12-01)

CXCL12 Mediated Regulation of the Cytoskeletal Regulator mDia2 Formin Induces Amoeboid Conversions and Cellular Plasticity in Migrating Human Breast Carcinoma Cells
by: Wyse, Meghan M.
Published: (2015)

Flightless-I (Fli-I) regulates the actin assembly activity of Diaphanous-related formins (DRFs), Daam1 and mDia1, in cooperation with active Rho GTPase
by: Ikeda, Tomoyuki
Published: (2011)

Induced Arp2/3 Complex Depletion Increases FMNL2/3 Formin Expression and Filopodia Formation
by: Vanessa Dimchev, et al.
Published: (2021-02-01)

The Role of mDia2 in Adherens Junctions in Epithelial Ovarian Cancer
by: Zhang, Yuqi
Published: (2019)

EphA4-dependent axon retraction and midline localization of Ephrin-B3 are disrupted in the spinal cord of mice lacking mDia1 and mDia3 in combination
by: Toyoda, Yosuke
Published: (2014)

Formation of transient lamellipodia.
by: Juliane Zimmermann, et al.
Published: (2014-01-01)

Actin polymerization-driven molecular movement of mDia1 in living cells
by: Higashida, Chiharu
Published: (2011)

Rho and anillin-dependent control of mDia2 localization and function in cytokinesis
by: Watanabe, Sadanori
Published: (2012)

Paxillin mediates sensing of physical cues and regulates directional cell motility by controlling lamellipodia positioning.
by: Julia E Sero, et al.
Published: (2011-01-01)

MTSS1 Regulation of Actin-Nucleating Formin DAAM1 in Dendritic Filopodia Determines Final Dendritic Configuration of Purkinje Cells
by: Kelly Kawabata Galbraith, et al.
Published: (2018-07-01)

Deficiency of mDia, an actin nucleator, disrupts integrity of neuroepithelium and causes periventricular dysplasia.
by: Dean Thumkeo, et al.
Published: (2011-01-01)

Impaired T lymphocyte trafficking in mice deficient in an actin-nucleating protein, mDia1
by: Sakata, Daiji
Published: (2011)

Deficiency of mDia, an actin nucleator, disrupts integrity of neuroepithelium and causes periventricular dysplasia
by: Thumkeo, Dean
Published: (2013)

Ena/VASP regulates mDia2-initiated filopodial length, dynamics, and function
by: Barzik, Melanie, et al.
Published: (2014)

Filopodia-independent roles of the actin bundling protein fascin in promoting cell motility
by: Oak, Youbean
Published: (2014)

mDia1 senses both force and torque during F-actin filament polymerization
by: Miao Yu, et al.
Published: (2017-11-01)

Rho-mDia1 pathway is required for adhesion, migration, and T cell stimulation in dendritic cells
by: Tanizaki, Hideaki
Published: (2011)

Dia-interacting protein (DIP) imposes migratory plasticity in mDia2-dependent tumor cells in three-dimensional matrices.
by: Meghan M Wyse, et al.
Published: (2012-01-01)

Concerted action of two formins in gliding motility and host cell invasion by Toxoplasma gondii.
by: Wassim Daher, et al.
Published: (2010-10-01)

Kif4 interacts with EB1 and stabilizes microtubules downstream of Rho-mDia in migrating fibroblasts.
by: Edward J Morris, et al.
Published: (2014-01-01)

Nuclear Actin Polymerized by mDia2 Confines Centromere Movement during CENP-A Loading
by: Chenshu Liu, et al.
Published: (2018-11-01)