Cerebrospinal fluid from Alzheimer’s disease patients promotes tau aggregation in transgenic mice

Cerebrospinal fluid from Alzheimer’s disease patients promotes tau aggregation in transgenic mice

Abstract Tau is a microtubule stabilizing protein that forms aggregates in Alzheimer’s disease (AD). Tau derived from AD patients’ brains induces tau aggregation in a prion-like manner when injected into susceptible mouse models. Here we investigated whether cerebrospinal fluid (CSF) collected from...

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Bibliographic Details
Main Authors: Zhiva Skachokova, Alfonso Martinisi, Martin Flach, Frederik Sprenger, Yvonne Naegelin, Viviane Steiner-Monard, Marc Sollberger, Andreas U. Monsch, Michel Goedert, Markus Tolnay, David T. Winkler
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
Neurodegeneration
Tau
Cerebrospinal fluid
Seeding
Prion
Online Access:http://link.springer.com/article/10.1186/s40478-019-0725-3

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