G6PD protects from oxidative damage and improves healthspan in mice

G6PD protects from oxidative damage and improves healthspan in mice

The enzyme G6PD generates the reductive metabolite NADPH, which has antioxidant effects, but has also been linked to tumour growth. Here the authors generate mice that modestly overexpress G6PD and report increased lifespan in females, and no negative effects on tumour formation in various genetic m...

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Main Authors: Sandrina Nóbrega-Pereira, Pablo J. Fernandez-Marcos, Thomas Brioche, Mari Carmen Gomez-Cabrera, Andrea Salvador-Pascual, Juana M. Flores, Jose Viña, Manuel Serrano
Format: Article
Language:English
Published: Nature Publishing Group 2016-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10894
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spelling doaj-82fba91b5bae472ea2ba057c123a0b712021-05-11T10:52:32ZengNature Publishing GroupNature Communications2041-17232016-03-01711910.1038/ncomms10894G6PD protects from oxidative damage and improves healthspan in miceSandrina Nóbrega-Pereira0Pablo J. Fernandez-Marcos1Thomas Brioche2Mari Carmen Gomez-Cabrera3Andrea Salvador-Pascual4Juana M. Flores5Jose Viña6Manuel Serrano7Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO)Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO)Université de Montpellier, INRA, UMR866, Dynamique Musculaire et MétabolismeDepartment of Physiology, Faculty of Medicine, University of Valencia and Investigaciòn Hospital Clínico Universitario (INCLIVA)Department of Physiology, Faculty of Medicine, University of Valencia and Investigaciòn Hospital Clínico Universitario (INCLIVA)Animal Surgery and Medicine Department, Faculty of Veterinary Sciences, Complutense University of MadridDepartment of Physiology, Faculty of Medicine, University of Valencia and Investigaciòn Hospital Clínico Universitario (INCLIVA)Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO)The enzyme G6PD generates the reductive metabolite NADPH, which has antioxidant effects, but has also been linked to tumour growth. Here the authors generate mice that modestly overexpress G6PD and report increased lifespan in females, and no negative effects on tumour formation in various genetic models.https://doi.org/10.1038/ncomms10894
collection DOAJ
language English
format Article
sources DOAJ
author Sandrina Nóbrega-Pereira
Pablo J. Fernandez-Marcos
Thomas Brioche
Mari Carmen Gomez-Cabrera
Andrea Salvador-Pascual
Juana M. Flores
Jose Viña
Manuel Serrano
spellingShingle Sandrina Nóbrega-Pereira
Pablo J. Fernandez-Marcos
Thomas Brioche
Mari Carmen Gomez-Cabrera
Andrea Salvador-Pascual
Juana M. Flores
Jose Viña
Manuel Serrano
G6PD protects from oxidative damage and improves healthspan in mice
Nature Communications
author_facet Sandrina Nóbrega-Pereira
Pablo J. Fernandez-Marcos
Thomas Brioche
Mari Carmen Gomez-Cabrera
Andrea Salvador-Pascual
Juana M. Flores
Jose Viña
Manuel Serrano
author_sort Sandrina Nóbrega-Pereira
title G6PD protects from oxidative damage and improves healthspan in mice
title_short G6PD protects from oxidative damage and improves healthspan in mice
title_full G6PD protects from oxidative damage and improves healthspan in mice
title_fullStr G6PD protects from oxidative damage and improves healthspan in mice
title_full_unstemmed G6PD protects from oxidative damage and improves healthspan in mice
title_sort g6pd protects from oxidative damage and improves healthspan in mice
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-03-01
description The enzyme G6PD generates the reductive metabolite NADPH, which has antioxidant effects, but has also been linked to tumour growth. Here the authors generate mice that modestly overexpress G6PD and report increased lifespan in females, and no negative effects on tumour formation in various genetic models.
url https://doi.org/10.1038/ncomms10894
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AT thomasbrioche g6pdprotectsfromoxidativedamageandimproveshealthspaninmice
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AT manuelserrano g6pdprotectsfromoxidativedamageandimproveshealthspaninmice
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