Regulation of cell-to-cell variability in divergent gene expression

Regulation of cell-to-cell variability in divergent gene expression

Gene expression noise affects cell fitness and development. Here, Yan et al. show that co-regulated divergent gene pairs (DGPs) suppress uncorrelated gene expression noise due to more synchronized transcription firing, and differentially regulated DGPs enhance gene expression noise due to transcript...

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Main Authors: Chao Yan, Shuyang Wu, Christopher Pocetti, Lu Bai
Format: Article
Language:English
Published: Nature Publishing Group 2016-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11099
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spelling doaj-82f8729b4630411bb2cb3f9dd984475d2021-05-11T11:19:42ZengNature Publishing GroupNature Communications2041-17232016-03-017111010.1038/ncomms11099Regulation of cell-to-cell variability in divergent gene expressionChao Yan0Shuyang Wu1Christopher Pocetti2Lu Bai3Department of Biochemistry and Molecular BiologyDepartment of Biochemistry and Molecular BiologyDepartment of Physics, The Pennsylvania State UniversityDepartment of Biochemistry and Molecular BiologyGene expression noise affects cell fitness and development. Here, Yan et al. show that co-regulated divergent gene pairs (DGPs) suppress uncorrelated gene expression noise due to more synchronized transcription firing, and differentially regulated DGPs enhance gene expression noise due to transcription leakage.https://doi.org/10.1038/ncomms11099
collection DOAJ
language English
format Article
sources DOAJ
author Chao Yan
Shuyang Wu
Christopher Pocetti
Lu Bai
spellingShingle Chao Yan
Shuyang Wu
Christopher Pocetti
Lu Bai
Regulation of cell-to-cell variability in divergent gene expression
Nature Communications
author_facet Chao Yan
Shuyang Wu
Christopher Pocetti
Lu Bai
author_sort Chao Yan
title Regulation of cell-to-cell variability in divergent gene expression
title_short Regulation of cell-to-cell variability in divergent gene expression
title_full Regulation of cell-to-cell variability in divergent gene expression
title_fullStr Regulation of cell-to-cell variability in divergent gene expression
title_full_unstemmed Regulation of cell-to-cell variability in divergent gene expression
title_sort regulation of cell-to-cell variability in divergent gene expression
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-03-01
description Gene expression noise affects cell fitness and development. Here, Yan et al. show that co-regulated divergent gene pairs (DGPs) suppress uncorrelated gene expression noise due to more synchronized transcription firing, and differentially regulated DGPs enhance gene expression noise due to transcription leakage.
url https://doi.org/10.1038/ncomms11099
work_keys_str_mv AT chaoyan regulationofcelltocellvariabilityindivergentgeneexpression
AT shuyangwu regulationofcelltocellvariabilityindivergentgeneexpression
AT christopherpocetti regulationofcelltocellvariabilityindivergentgeneexpression
AT lubai regulationofcelltocellvariabilityindivergentgeneexpression
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