Pediatric Diffuse Midline Gliomas H3 K27M-Mutant and Non-Histone Mutant Midline High-Grade Gliomas in Neurofibromatosis Type 1 in Comparison With Non-Syndromic Children: A Single-Center Pilot Study

Pediatric Diffuse Midline Gliomas H3 K27M-Mutant and Non-Histone Mutant Midline High-Grade Gliomas in Neurofibromatosis Type 1 in Comparison With Non-Syndromic Children: A Single-Center Pilot Study

Background: Pediatric neurofibromatosis type 1 (NF1) patients rarely develop aggressive central nervous system tumors. Among high-grade gliomas (HGGs), histone mutant diffuse midline gliomas (DMGs H3 K27M-mutant) have exceptionally been reported. The aim of this retrospectives single-center study wa...

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Bibliographic Details
Main Authors: Federica Garibotto, Francesca Madia, Claudia Milanaccio, Antonio Verrico, Arnoldo Piccardo, Domenico Tortora, Gianluca Piatelli, Maria Cristina Diana, Valeria Capra, Maria Luisa Garrè, Andrea Rossi, Giovanni Morana
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Oncology
Subjects:
H3K27M
pediatric
brain tumor
diffuse midline glioma
NF1
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00795/full

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