Hypoxia Selectively Impairs CAR-T Cells In Vitro

Hypoxia Selectively Impairs CAR-T Cells In Vitro

Hypoxia is a major characteristic of the solid tumor microenvironment. To understand how chimeric antigen receptor-T cells (CAR-T cells) function in hypoxic conditions, we characterized CD19-specific and BCMA-specific human CAR-T cells generated in atmospheric (18% oxygen) and hypoxic (1% oxygen) cu...

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Bibliographic Details
Main Authors: Robert Berahovich, Xianghong Liu, Hua Zhou, Elias Tsadik, Shirley Xu, Vita Golubovskaya, Lijun Wu
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cancers
Subjects:
CAR-T
hypoxia
tumor
microenvironment
CD19
BCMA
immunotherapy
Online Access:https://www.mdpi.com/2072-6694/11/5/602

Internet

https://www.mdpi.com/2072-6694/11/5/602

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