Multi-omics profiling of primary small cell carcinoma of the esophagus reveals RB1 disruption and additional molecular subtypes

Multi-omics profiling of primary small cell carcinoma of the esophagus reveals RB1 disruption and additional molecular subtypes

Primary small cell carcinoma of the oesophagus has a poor prognosis, and has not been fully characterised molecularly. Here, the authors study the disease using multi-omics technology and find frequent RB1 disruptions and similarities to small cell lung cancer, opening potential therapeutic avenues.

Bibliographic Details
Main Authors: Renda Li, Zhenlin Yang, Fei Shao, Hong Cheng, Yaru Wen, Sijin Sun, Wei Guo, Zitong Li, Fan Zhang, Liyan Xue, Nan Bi, Jie Wang, Yingli Sun, Yin Li, Fengwei Tan, Qi Xue, Shugeng Gao, Susheng Shi, Yibo Gao, Jie He
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24043-6

Internet

https://doi.org/10.1038/s41467-021-24043-6

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