Prognostic Role of Intragastric Cytopathology and Microbiota in Surgical Patients with Stomach Cancer

• Main Authors: Edoardo Virgilio, Enrico Giarnieri, Elisabetta Carico, Monica Montagnini, Sandra Villani, Michele Fiorenti, Marco Cavallini, Filippo Montali, Renato Costi
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2021-01-01
• Series: Journal of Cytology
• Subjects: fluid cytology; gastric cancer; gastric microbiota; gastrointestinal cytology; non-gynecologic cytopathology
• Online Access: http://www.jcytol.org/article.asp?issn=0970-9371;year=2021;volume=38;issue=2;spage=82;epage=87;aulast=Virgilio

Background: In the last decade, analysis of malignant cells and flora in gastric lavage (GL) has provided interesting data on pathogenesis of gastric cancer (GC). For this study, combining such two aspects into one cyto-microbiologic category, we tested the prognostic role of the presence/absence of cancer cells (GL1/GL0) and bacterial microbiota (MB1/MB0) in our GC population. Material and Methods: Between April 2012 and August 2019, 79 surgical patients with GC were prospectively investigated with the determination of GL MB. Results: Compared with GL1 MB0, GL1 MB1 strongly correlated with advanced GC, portended poorer overall survival (OS) (45.8 months vs 20.5 months, P = 0.049), and resulted a significant (P = 0.008) and an independent (P = 0.013) prognostic factor unfavorable for OS. Conclusion: In the light of our results, the cyto-microbiologic parameter of GL MB should be used to gain a better prognosis of GC patients. Administration of antimicrobial treatment for MB1 subjects should be entertained because it could reduce the risk of oncogenesis.