Activation of GSK-3β and caspase-3 occurs in Nigral dopamine neurons during the development of apoptosis activated by a striatal injection of 6-hydroxydopamine.
The 6-Hydroxydopamine (6-OHDA) rat model of Parkinson's disease is essential for a better understanding of the pathological processes underlying the human disease and for the evaluation of promising therapeutic interventions. This work evaluated whether a single striatal injection of 6-OHDA cau...
Main Authors: | Daniel Hernandez-Baltazar, Maria E Mendoza-Garrido, Daniel Martinez-Fong |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
|
Series: | PLoS ONE |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23940672/?tool=EBI |
Similar Items
-
Striatal and nigral muscarinic type 1 and type 4 receptors modulate levodopa-induced dyskinesia and striato-nigral pathway activation in 6-hydroxydopamine hemilesioned rats
by: Alberto Brugnoli, et al.
Published: (2020-10-01) -
Aqueous Extract of Davallia mariesii Attenuates 6-Hydroxydopamine-Induced Oxidative Damage and Apoptosis in B35 Cells Through Inhibition of Caspase Cascade and Activation of PI3K/AKT/GSK-3β Pathway
by: Chi-Rei Wu, et al.
Published: (2018-10-01) -
Chondroitinase ABC reduces dopaminergic nigral cell death and striatal terminal loss in a 6-hydroxydopamine partial lesion mouse model of Parkinson’s disease
by: Edward J. R. Fletcher, et al.
Published: (2019-12-01) -
Methamphetamine-induced dopamine-independent alterations in striatal gene expression in the 6-hydroxydopamine hemiparkinsonian rats.
by: Jean Lud Cadet, et al.
Published: (2010-12-01) -
Impact of age and vector construct on striatal and nigral transgene expression
by: Nicole K Polinski, et al.
Published: (2016-01-01)