A Textile-Based Microfluidic Platform for the Detection of Cytostatic Drug Concentration in Sweat Samples

• Main Authors: Goran M. Stojanović, Maja M. Radetić, Zoran V. Šaponjić, Marija B. Radoičić, Milan R. Radovanović, Željko V. Popović, Saša N. Vukmirović
• Format: Article
• Language: English
• Published: MDPI AG 2020-06-01
• Series: Applied Sciences
• Subjects: cotton; polyester; polyaniline/TiO₂; microfluidics; sweat; cyclophosphamide
• Online Access: https://www.mdpi.com/2076-3417/10/12/4392

This work presents a new multilayered microfluidic platform, manufactured using a rapid and cost-effective xurography technique, for the detection of drug concentrations in sweat. Textile fabrics made of cotton and polyester were used as a component of the platform, and they were positioned in the middle of the microfluidic device. In order to obtain a highly conductive textile, the fabrics were in situ coated with different amounts of polyaniline and titanium dioxide nanocomposite. This portable microfluidic platform comprises at least three layers of optically transparent and flexible PVC foils which were stacked one on top of the other. Electrical contacts were provided from the edge of the textile material when a microfluidic variable resistor was actually created. The platform was tested in plain artificial sweat and in artificial sweat with a dissolved cytostatic test drug, cyclophosphamide, of different concentrations. The proposed microfluidic device decreased in resistance when the sweat was applied. In addition, it could successfully detect different concentrations of cytostatic medication in the sweat, which could make it a very useful tool for simple, reliable, and fast diagnostics.