Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism

Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism

Abstract TRPML1 channel is a non-selective group-2 transient receptor potential (TRP) channel with Ca2+ permeability. Located mainly in late endosome and lysosome of all mammalian cell types, TRPML1 is indispensable in the processes of endocytosis, membrane trafficking, and lysosome biogenesis. Muta...

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Bibliographic Details
Main Authors: Sensen Zhang, Ningning Li, Wenwen Zeng, Ning Gao, Maojun Yang
Format: Article
Language:English
Published: SpringerOpen 2017-09-01
Series:Protein & Cell
Subjects:
mTRPML1
mucolipidosis type IV
structual comparisons
combined regulation mechanism
Online Access:http://link.springer.com/article/10.1007/s13238-017-0476-5

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http://link.springer.com/article/10.1007/s13238-017-0476-5

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