Structural and Biological Investigations for a Series of N-5 Substituted Pyrrolo[3,2-<i>d</i>]pyrimidines as Potential Anti-Cancer Therapeutics

Structural and Biological Investigations for a Series of N-5 Substituted Pyrrolo[3,2-<i>d</i>]pyrimidines as Potential Anti-Cancer Therapeutics

Pyrrolo[3,2-<i>d</i>]pyrimidines have been studied for many years as potential lead compounds for the development of antiproliferative agents. Much of the focus has been on modifications to the pyrimidine ring, with enzymatic recognition often modulated by C2 and C4 substituents. In cont...

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Bibliographic Details
Main Authors:	Brian M. Cawrse, Nia’mani M. Robinson, Nina C. Lee, Gerald M. Wilson, Katherine L. Seley-Radtke
Format:	Article
Language:	English
Published:	MDPI AG 2019-07-01
Series:	Molecules
Subjects:	pyrrolo[3,2-<i>d</i>]pyrimidine anti-cancer antiproliferative DNA damage DNA alkylator
Online Access:	https://www.mdpi.com/1420-3049/24/14/2656

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