SARS-CoV-2 Virion Stabilization by Zn Binding

SARS-CoV-2 Virion Stabilization by Zn Binding

Zinc plays a crucial role in the process of virion maturation inside the host cell. The accessory Cys-rich proteins expressed in SARS-CoV-2 by genes ORF7a and ORF8 are likely involved in zinc binding and in interactions with cellular antigens activated by extensive disulfide bonds. In this report we...

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Bibliographic Details
Main Authors: Silvia Morante, Giovanni La Penna, Giancarlo Rossi, Francesco Stellato
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Molecular Biosciences
Subjects:
SARS-CoV-2
Zn binding
molecular dynamics computer simulation
zinc finger
tetherin/Bst2
orf7a and orf8 proteins
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.00222/full

Internet

https://www.frontiersin.org/article/10.3389/fmolb.2020.00222/full

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