Effector Protein Cig2 Decreases Host Tolerance of Infection by Directing Constitutive Fusion of Autophagosomes with the Coxiella-Containing Vacuole

Effector Protein Cig2 Decreases Host Tolerance of Infection by Directing Constitutive Fusion of Autophagosomes with the Coxiella-Containing Vacuole

Coxiella burnetii replicates in an acidified lysosome-derived vacuole. Biogenesis of the Coxiella-containing vacuole (CCV) requires bacterial effector proteins delivered into host cells by the Dot/Icm secretion system. Genetic and cell biological analysis revealed that an effector protein called Cig...

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Bibliographic Details
Main Authors:	Lara J. Kohler, Shawna R. Reed, Shireen A. Sarraf, David D. Arteaga, Hayley J. Newton, Craig R. Roy
Format:	Article
Language:	English
Published:	American Society for Microbiology 2016-07-01
Series:	mBio
Online Access:	http://mbio.asm.org/cgi/content/full/7/4/e01127-16

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