Glial-neuronal signaling mechanisms underlying the neuroinflammatory effects of manganese

Glial-neuronal signaling mechanisms underlying the neuroinflammatory effects of manganese

Abstract Background Exposure to increased manganese (Mn) causes inflammation and neuronal injury in the cortex and basal ganglia, resulting in neurological symptoms resembling Parkinson’s disease. The mechanisms underlying neuronal death from exposure to Mn are not well understood but involve inflam...

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Bibliographic Details
Main Authors: Katriana A. Popichak, Maryam F. Afzali, Kelly S. Kirkley, Ronald B. Tjalkens
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Journal of Neuroinflammation
Subjects:
Neuroinflammation
Manganism
Astrocyte
Glial-glial communication
Glial-neuronal communication
NF-κB
Online Access:http://link.springer.com/article/10.1186/s12974-018-1349-4

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http://link.springer.com/article/10.1186/s12974-018-1349-4

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