The rationale for preventing cancer cachexia: targeting excessive fatty acid oxidation
Abstract Cachexia commonly occurs at the terminal stage of cancer and has largely unclear molecular mechanisms. A recent study published in Nature Medicine, entitled “Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia,” reveals that cachectic cancer cells can secrete multiple c...
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2016-07-01
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| Series: | Chinese Journal of Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s40880-016-0129-8 |
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doaj-829cde1604f64ce4ba19f6a1ee7554322020-11-25T00:49:45ZengBMCChinese Journal of Cancer1944-446X2016-07-013511210.1186/s40880-016-0129-8The rationale for preventing cancer cachexia: targeting excessive fatty acid oxidationChao-Nan Qian0Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer MedicineAbstract Cachexia commonly occurs at the terminal stage of cancer and has largely unclear molecular mechanisms. A recent study published in Nature Medicine, entitled “Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia,” reveals that cachectic cancer cells can secrete multiple cytokines that induce excessive fatty acid oxidation, which is responsible for muscle loss in cancer cachexia. Inhibition of fatty acid oxidation using etomoxir can increase muscle mass and body weight in cancer cachexia animal models. The usage of stable cachexia animal models is also discussed in this research highlight.http://link.springer.com/article/10.1186/s40880-016-0129-8CachexiaCancerFatty acid oxidation |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Chao-Nan Qian |
| spellingShingle |
Chao-Nan Qian The rationale for preventing cancer cachexia: targeting excessive fatty acid oxidation Chinese Journal of Cancer Cachexia Cancer Fatty acid oxidation |
| author_facet |
Chao-Nan Qian |
| author_sort |
Chao-Nan Qian |
| title |
The rationale for preventing cancer cachexia: targeting excessive fatty acid oxidation |
| title_short |
The rationale for preventing cancer cachexia: targeting excessive fatty acid oxidation |
| title_full |
The rationale for preventing cancer cachexia: targeting excessive fatty acid oxidation |
| title_fullStr |
The rationale for preventing cancer cachexia: targeting excessive fatty acid oxidation |
| title_full_unstemmed |
The rationale for preventing cancer cachexia: targeting excessive fatty acid oxidation |
| title_sort |
rationale for preventing cancer cachexia: targeting excessive fatty acid oxidation |
| publisher |
BMC |
| series |
Chinese Journal of Cancer |
| issn |
1944-446X |
| publishDate |
2016-07-01 |
| description |
Abstract Cachexia commonly occurs at the terminal stage of cancer and has largely unclear molecular mechanisms. A recent study published in Nature Medicine, entitled “Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia,” reveals that cachectic cancer cells can secrete multiple cytokines that induce excessive fatty acid oxidation, which is responsible for muscle loss in cancer cachexia. Inhibition of fatty acid oxidation using etomoxir can increase muscle mass and body weight in cancer cachexia animal models. The usage of stable cachexia animal models is also discussed in this research highlight. |
| topic |
Cachexia Cancer Fatty acid oxidation |
| url |
http://link.springer.com/article/10.1186/s40880-016-0129-8 |
| work_keys_str_mv |
AT chaonanqian therationaleforpreventingcancercachexiatargetingexcessivefattyacidoxidation AT chaonanqian rationaleforpreventingcancercachexiatargetingexcessivefattyacidoxidation |
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