Dot1l interacts with Zc3h10 to activate Ucp1 and other thermogenic genes

Dot1l interacts with Zc3h10 to activate Ucp1 and other thermogenic genes

Brown adipose tissue is a metabolically beneficial organ capable of dissipating chemical energy into heat, thereby increasing energy expenditure. Here, we identify Dot1l, the only known H3K79 methyltransferase, as an interacting partner of Zc3h10 that transcriptionally activates the Ucp1 promoter an...

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Bibliographic Details
Main Authors: Danielle Yi, Hai P Nguyen, Jennie Dinh, Jose A Viscarra, Ying Xie, Frances Lin, Madeleine Zhu, Jon M Dempersmier, Yuhui Wang, Hei Sook Sul
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-10-01
Series:eLife
Subjects:
brown adipose tissue
transcription
thermogenesis
Online Access:https://elifesciences.org/articles/59990

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