GSH attenuates RANKL-induced osteoclast formation in vitro and LPS-induced bone loss in vivo

GSH attenuates RANKL-induced osteoclast formation in vitro and LPS-induced bone loss in vivo

Osteoclasts are capable of adhering the bone matrix, then secrete acid and lytic enzymes to resorb it. Reactive oxygen species (ROS), as a signaling messenger, plays an important role in the receptor activator nuclear factor κB ligand (RANKL) signal pathway during osteoclast differentiation. Glutath...

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Bibliographic Details
Main Authors: Bing Han, Huan Geng, Liang Liu, Zhixin Wu, Yizhong Wang
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Glutathione
Bone loss
Differentiation
Reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220304972

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