Acutely increasing δGABAA receptor activity impairs memory and inhibits synaptic plasticity in the hippocampus

Acutely increasing δGABAA receptor activity impairs memory and inhibits synaptic plasticity in the hippocampus

Extrasynaptic γ-aminobutyric acid type A (GABAA) receptors that contain the δ subunit (δGABAA receptors) are expressed in several brain regions including the dentate gyrus (DG) and CA1 subfields of the hippocampus. Drugs that increase δGABAA receptor activity have been proposed as treatments for a v...

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Bibliographic Details
Main Authors: Paul David Whissell, Dave eEng, Irene eLecker, Dian-Shi eWang, Loren John Martin, Beverley Anne Orser
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-09-01
Series:Frontiers in Neural Circuits
Subjects:
Dentate Gyrus
Long-Term Potentiation
Memory
CA1
tonic inhibition
THIP
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncir.2013.00146/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncir.2013.00146/full

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