HLA-G orchestrates the early interaction of human trophoblasts with the maternal niche

HLA-G orchestrates the early interaction of human trophoblasts with the maternal niche

Extravillous trophoblasts (EVTs) play a central role in educating maternal leukocytes, endometrial stromal and endothelial cells to generate a receptive decidual microenvironment tailored to accept the semi-allogeneic fetus. HLA-G, a non-classical HLA class I molecules endowed with immune-regulatory...

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Bibliographic Details
Main Authors: Silvia eGregori, Giada eAmodio, Federica eQuattrone, Paola ePanina-Bordignon
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Immunology
Subjects:
Decidua
Dendritic Cells
Trophoblasts
tolerance
vascular remodeling
IL10
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00128/full

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