Selective Inhibition of Human AKR1B10 by <i>n</i>-Humulone, Adhumulone and Cohumulone Isolated from <i>Humulus lupulus</i> Extract

Selective Inhibition of Human AKR1B10 by <i>n</i>-Humulone, Adhumulone and Cohumulone Isolated from <i>Humulus lupulus</i> Extract

Hop-derived compounds have been subjected to numerous biomedical studies investigating their impact on a wide range of pathologies. Isomerised bitter acids (isoadhumulone, isocohumulone and isohumulone) from hops, used in the brewing process of beer, are known to inhibit members of the aldo-keto-red...

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Bibliographic Details
Main Authors: Jan Moritz Seliger, Serhat Sezai Cicek, Lydia T. Witt, Hans-Jörg Martin, Edmund Maser, Jan Hintzpeter
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Molecules
Subjects:
aldo-keto reductases
cancer
tight-binding inhibition
selective inhibition
humulone
farnesal reduction
hops
humulus lupulus
alpha-acids
Online Access:https://www.mdpi.com/1420-3049/23/11/3041

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