Structural identification of N-glycan isomers using logically derived sequence tandem mass spectrometry

Structural identification of N-glycan isomers using logically derived sequence tandem mass spectrometry

Mass spectrometry can be used for structural determination of N-glycans, but commonly requires prior derivatisation or comparison to a library of standards. Here logically-derived sequence tandem mass spectrometry allows for assignment of native N-glycans by analysis of successive fragmentation patt...

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Main Authors: Chia Yen Liew, Chu-Chun Yen, Jien-Lian Chen, Shang-Ting Tsai, Sujeet Pawar, Chung-Yi Wu, Chi-Kung Ni
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-021-00532-z
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spelling doaj-8253fbb5f0b24bfb8e4abc3ad6bd08f42021-06-20T11:05:34ZengNature Publishing GroupCommunications Chemistry2399-36692021-06-014111110.1038/s42004-021-00532-zStructural identification of N-glycan isomers using logically derived sequence tandem mass spectrometryChia Yen Liew0Chu-Chun Yen1Jien-Lian Chen2Shang-Ting Tsai3Sujeet Pawar4Chung-Yi Wu5Chi-Kung Ni6Institute of Atomic and Molecular Sciences, Academia SinicaInstitute of Atomic and Molecular Sciences, Academia SinicaInstitute of Atomic and Molecular Sciences, Academia SinicaInstitute of Atomic and Molecular Sciences, Academia SinicaGenomics Research Center, Academia SinicaGenomics Research Center, Academia SinicaInstitute of Atomic and Molecular Sciences, Academia SinicaMass spectrometry can be used for structural determination of N-glycans, but commonly requires prior derivatisation or comparison to a library of standards. Here logically-derived sequence tandem mass spectrometry allows for assignment of native N-glycans by analysis of successive fragmentation patterns without derivatisation and standards.https://doi.org/10.1038/s42004-021-00532-z
collection DOAJ
language English
format Article
sources DOAJ
author Chia Yen Liew
Chu-Chun Yen
Jien-Lian Chen
Shang-Ting Tsai
Sujeet Pawar
Chung-Yi Wu
Chi-Kung Ni
spellingShingle Chia Yen Liew
Chu-Chun Yen
Jien-Lian Chen
Shang-Ting Tsai
Sujeet Pawar
Chung-Yi Wu
Chi-Kung Ni
Structural identification of N-glycan isomers using logically derived sequence tandem mass spectrometry
Communications Chemistry
author_facet Chia Yen Liew
Chu-Chun Yen
Jien-Lian Chen
Shang-Ting Tsai
Sujeet Pawar
Chung-Yi Wu
Chi-Kung Ni
author_sort Chia Yen Liew
title Structural identification of N-glycan isomers using logically derived sequence tandem mass spectrometry
title_short Structural identification of N-glycan isomers using logically derived sequence tandem mass spectrometry
title_full Structural identification of N-glycan isomers using logically derived sequence tandem mass spectrometry
title_fullStr Structural identification of N-glycan isomers using logically derived sequence tandem mass spectrometry
title_full_unstemmed Structural identification of N-glycan isomers using logically derived sequence tandem mass spectrometry
title_sort structural identification of n-glycan isomers using logically derived sequence tandem mass spectrometry
publisher Nature Publishing Group
series Communications Chemistry
issn 2399-3669
publishDate 2021-06-01
description Mass spectrometry can be used for structural determination of N-glycans, but commonly requires prior derivatisation or comparison to a library of standards. Here logically-derived sequence tandem mass spectrometry allows for assignment of native N-glycans by analysis of successive fragmentation patterns without derivatisation and standards.
url https://doi.org/10.1038/s42004-021-00532-z
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AT shangtingtsai structuralidentificationofnglycanisomersusinglogicallyderivedsequencetandemmassspectrometry
AT sujeetpawar structuralidentificationofnglycanisomersusinglogicallyderivedsequencetandemmassspectrometry
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