Liver chimeric mice with tupaia hepatocyte transplantation as an animal model for hepatitis B virus infection and antiviral therapy

Liver chimeric mice with tupaia hepatocyte transplantation as an animal model for hepatitis B virus infection and antiviral therapy

The human liver chimeric mouse is a milestone animal model for hepatitis B virus (HBV) infection. Such mice with primary human hepatocyte (PHH) transplantation are adequate to support chronic HBV infection for several weeks and to evaluate antiviral drugs. However, the drawbacks of PHHs include lack...

Full description

Bibliographic Details
Main Authors:	Lunzhi Yuan, Yao Chen, Xuan Liu, Yali Zhang, Ming Zhou, Kun Wu, Quan Yuan, Tong Cheng, Ningshao Xia
Format:	Article
Language:	English
Published:	Elsevier 2019-09-01
Series:	Biosafety and Health
Subjects:	Tupaia Hepatitis B Liver chimeric mice Infectious animal model Antiviral therapy
Online Access:	http://www.sciencedirect.com/science/article/pii/S2590053619300242

Similar Items

Advances in Animal Models of Hepatitis B Virus Infection
by: Zhang Hang
Published: (2015-12-01)

Primary Tupaia javanica Hepatocytes Cultures As In Vitro Replication System for Ape Hepatitis B Viruses
by: MARYATI SURYA, et al.
Published: (2016-07-01)

Body mass, Thermogenesis and energy metabolism in Tupaia belangeri during cold acclimation
by: Wan-long Zhu, et al.
Published: (2012-05-01)

Tupaia: Palingenesis of a Polynesian Epic Hero
by: Elena Traina
Published: (2020-12-01)

Experimental chronic hepatitis B infection of neonatal tree shrews (<it>Tupaia belangeri chinensis</it>): A model to study molecular causes for susceptibility and disease progression to chronic hepatitis in humans
by: Wang Qi, et al.
Published: (2012-08-01)

First report of Schistosoma sinensium infecting Tupaia belangeri and Tricula sp. LF
by: Xuan Wang, et al.
Published: (2021-04-01)

Variations of Endocrine Hormones Concentrations in Tupaia belangeri under Simulated Seasonal Acclimatized: Role of Leptin Sensitivity
by: Zhu, Wan-long, et al.
Published: (2013-04-01)

Metabolism and thermoregulation in the tree shrew, Tupaia belangeri
by: Lin Zhang, et al.
Published: (2012-05-01)

Effects of Gradient Photoperiod and Temperature on Energy Metabolism and Body Composition in Tupaia belangeri chinensis
by: Zhu, Wanlong, et al.
Published: (2013-02-01)

Tree shrew (Tupaia belangeri) as a novel laboratory disease animal model
by: Ji Xiao, et al.
Published: (2017-05-01)

Effects of Photoperiod and Temperature on Energy Budgets and Endocrine Hormones Concentrations in Tupaia belangeri
by: Wan-long Zhu, et al.
Published: (2014-03-01)

Study of chemical communication based on urine in tree shrews Tupaia belangeri (Mammalia: Scandentia: Tupaiidae)
by: Z. Wanlong, et al.
Published: (2017-01-01)

The relationship among metabolic rate of tree shrews (Tupaia belangeri) under cold acclimation
by: Lin Zhang, et al.
Published: (2012-11-01)

Notes on the distribution, habitat, and behavior of Northern Tree Shrew Tupaia belangeri (Mammalia: Scandentia: Tupaiidae) in Tripura, India
by: Joydeb Majumder, et al.
Published: (2015-01-01)

Notes on the distribution, habitat, and behavior of Northern Tree Shrew Tupaia belangeri (Mammalia: Scandentia: Tupaiidae) in Tripura, India
by: Joydeb Majumder, et al.
Published: (2015-01-01)

Detection and genome characterization of two novel papillomaviruses and a novel polyomavirus in tree shrew (Tupaia belangeri chinensis) in China
by: Ping Liu, et al.
Published: (2019-03-01)

A Chimeric Humanized Mouse Model by Engrafting the Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cell for the Chronic Hepatitis B Virus Infection
by: Lunzhi Yuan, et al.
Published: (2018-05-01)

Dispersal and genetic structure in a tropical small mammal, the Bornean tree shrew (Tupaia longipes), in a fragmented landscape along the Kinabatangan River, Sabah, Malaysia
by: Jennifer Brunke, et al.
Published: (2020-04-01)

Description of Sarcocystis scandentiborneensis sp. nov. from treeshrews (Tupaia minor, T. tana) in northern Borneo with annotations on the utility of COI and 18S rDNA sequences for species delineation
by: Paula Ortega Pérez, et al.
Published: (2020-08-01)

Neural Progenitors in the Developing Neocortex of the Northern Tree Shrew (Tupaia belangeri) Show a Closer Relationship to Gyrencephalic Primates Than to Lissencephalic Rodents
by: Sebastian Römer, et al.
Published: (2018-04-01)

Epigallocatechin gallate inhibits hepatitis B virus infection in human liver chimeric mice
by: Yu-Heng Lai, et al.
Published: (2018-09-01)

cccDNA Maintenance in Chronic Hepatitis B – Targeting the Matrix of Viral Replication
by: Dandri M, et al.
Published: (2020-10-01)

HCV Animal Models: A Journey of More than 30 Years
by: Philip Meuleman, et al.
Published: (2009-09-01)

Enzyme activity, hormone concentration in tree shrew (Tupaia belangeri) during cold acclimation
by: Lin Zhang, et al.
Published: (2012-08-01)

Comparison of Nonshivering Thermogenesis Induced by Norepinephrine Stress in Tree Shrews
by: Wan-long Zhu, et al.
Published: (2013-11-01)

Tree shrew (Tupaia belangeri chinensis), a novel non-obese animal model of non-alcoholic fatty liver disease
by: Linqiang Zhang, et al.
Published: (2016-10-01)

Strong Replication Interference Between Hepatitis Delta Viruses in Human Liver Chimeric Mice
by: Katja Giersch, et al.
Published: (2021-07-01)

Efficient chimeric mouse production using a novel embryonic stem cell line
by: G. V. Kontsevaya, et al.
Published: (2017-02-01)

Bone marrow cell migration to the heart in a chimeric mouse model of acute chagasic disease
by: Camila Iansen Irion, et al.

Characterization and applications of chimeric mice with humanized livers for preclinical drug development
by: Chise Tateno, et al.
Published: (2020-01-01)

Development of AAV Variants with Human Hepatocyte Tropism and Neutralizing Antibody Escape Capacity
by: Xiaolei Pei, et al.
Published: (2020-09-01)

Editorial: Immunotherapeutic and Immunoprophylactic Strategies for Infectious Diseases
by: Giuseppe A. Sautto, et al.
Published: (2020-07-01)

Antiviral therapy of HCV in the cirrhotic and transplant candidate
Published: (2006-04-01)

Hepatitis Delta Virus Acts as an Immunogenic Adjuvant in Hepatitis B Virus-Infected Hepatocytes
by: Christine Y.L. Tham, et al.
Published: (2020-07-01)

Low Level Donor Chimerism of CD19 CAR-T Cells Returned to Complete Donor Chimerism in Patients with Relapse After Allo-Hematopoietic Stem Cell Transplant
by: Li Q, et al.
Published: (2020-11-01)

Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer’s disease
by: Christel Claes, et al.
Published: (2021-07-01)

Mesothelin is a target of chimeric antigen receptor T cells for treating gastric cancer
by: Jiang Lv, et al.
Published: (2019-02-01)

Interferon Response in Hepatitis C Virus-Infected Hepatocytes: Issues to Consider in the Era of Direct-Acting Antivirals
by: Pil Soo Sung, et al.
Published: (2020-04-01)

Chimerism Analysis in Bone Marrow Transplantation
by: Ebru Dundar Yenilmez, et al.
Published: (2014-02-01)

Efficiency of Antiviral Therapy for Recurrence of Chronic Hepatitis C in Patients Undergoing Liver Transplantation
by: A. A. Sukhoruk, et al.
Published: (2014-09-01)