Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells

Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells

Abstract Background The tumor suppressor actions of hexamethylene bis-acetamide (HMBA)-inducible protein 1 (HEXIM1) in the breast, prostate, melanomas, and AML have been reported by our group and others. Increased HEXIM1 expression caused differentiation and inhibited proliferation and metastasis of...

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Bibliographic Details
Main Authors: Monica M. Montano, I-Ju Yeh, Yinghua Chen, Chris Hernandez, Janna G. Kiselar, Maria de la Fuente, Adriane M. Lawes, Marvin T. Nieman, Philip D. Kiser, James Jacobberger, Agata A. Exner, Matthew C. Lawes
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Breast Cancer Research
Subjects:
HEXIM1 inducers
KDM5B
Breast cancer
Differentiation
Online Access:https://doi.org/10.1186/s13058-019-1228-7

Internet

https://doi.org/10.1186/s13058-019-1228-7

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