Avaliação da lesão muscular após estiramento controlado em ratos diabéticos
Introduction: Diabetes is a multifactorial autoimmune disease whose susceptibility is determined by chemical, genetic and environmental factors. Objective: Evaluate functional and biochemical parameters of inflammation after muscle injury in diabetic rats. Methods: Through a plantar flexion was perf...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Portuguese |
| Published: |
Universidade Nove de Julho
2011-01-01
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| Series: | ConScientiae Saúde |
| Online Access: | http://www.redalyc.org/articulo.oa?id=92919297001 |
| Summary: | Introduction: Diabetes is a multifactorial autoimmune disease whose susceptibility is determined by chemical, genetic and environmental factors. Objective: Evaluate functional and biochemical parameters of inflammation after muscle injury in diabetic rats. Methods: Through a plantar flexion was performed controlled stretch the tibialis anterior muscle in groups les (n=5) and les+diab (n=5). The protein extravasation was determined by Evans Blue, cytokines TNF-a, IL- 1B, IL-6 and IL-10 by ELISA and functional evaluation by walking track analysis. Results: We observed an increase in protein extravasation in groups les and
les+diab compared to the healthy group (p<0.01 and p<0.05). There was a significant increase of TNF-a, IL-10 and IL-6 groups les, les+diab and diab (p<0.001) and IL-1B les groups (p <0.05) les+diab and diab (p<0.01) compared to the healthy group. We observed an increase in the functional index les group (p<0.001) and les+diab (p<0.01) compared to the healthy group and the group diab. Conclusion: The controlled stretch injury in the tibial anterior muscle of rats, induce an immune response reduced in diabetic animals and a deficit in motor function. |
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| ISSN: | 1677-1028 1983-9324 |