Human bone marrow-derived mesenchymal stem cells promote the growth and drug-resistance of diffuse large B-cell lymphoma by secreting IL-6 and elevating IL-17A levels

Human bone marrow-derived mesenchymal stem cells promote the growth and drug-resistance of diffuse large B-cell lymphoma by secreting IL-6 and elevating IL-17A levels

Abstract Background The drug-resistance and relapse of diffuse large B-cell lymphoma (DLBCL), which are related to mesenchymal stem cells (MSCs), have become increasingly common. However, the underlying mechanisms remain elusive. Methods CCK 8 assay, colony formation assay, and xenograft mouse model...

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Bibliographic Details
Main Authors: Weijie Zhong, Zhigang Zhu, Xin Xu, Hui Zhang, Huabao Xiong, Qingshan Li, Yaming Wei
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Mesenchymal stem cells
Interleukin-6
Interleukin-17A
Drug-resistance
Lymphoma, large B cell, diffuse
JAK2/STAT3
Online Access:http://link.springer.com/article/10.1186/s13046-019-1081-7

Internet

http://link.springer.com/article/10.1186/s13046-019-1081-7

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