Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity
Deubiquitinating enzymes (DUBs) are critical regulators of cellular processes by removing ubiquitin from specific targets. Here global kinetic modelling reveals the mechanism by which the low intrinsic activity of USP7 is substantially enhanced on a specific physiological target.
Bibliographic Details
| Main Authors: |
Robbert Q. Kim,
Paul P. Geurink,
Monique P. C. Mulder,
Alexander Fish,
Reggy Ekkebus,
Farid El Oualid,
Willem J. van Dijk,
Duco van Dalen,
Huib Ovaa,
Hugo van Ingen,
Titia K. Sixma |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2019-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-08231-5
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